Expression of galectin-1 in malignant tumors
Galectin-1 is a 14 kDa lectin expressed ubiquitously in mammalian organism. Since its discovery, the lectin was shown to participate in many cellular processes. Involvement in some of them like induction of apoptosis of activated T cells, mediation of cell adhesion and participation in angiogenesi...
Saved in:
| Date: | 2009 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
|
| Series: | Experimental Oncology |
| Subjects: | |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/135729 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Expression of galectin-1 in malignant tumors / D. Demydenko, I. Berest // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 74-79. — Бібліогр.: 74 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Galectin-1 is a 14 kDa lectin expressed ubiquitously in mammalian organism. Since its discovery, the lectin was shown to participate
in many cellular processes. Involvement in some of them like induction of apoptosis of activated T cells, mediation of cell adhesion
and participation in angiogenesis suggest that galectin-1 could be utilized by malignant tumors. Indeed expression of galectin-1 is
upregulated in tumors of different origin. Many examples point to its important role in a process of cancer metastasis. This review
summarizes the data available to date on galectin-1 expression in human malignancies. |
|---|