Crossing chromosomes in pleomorphic sarcoma
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
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| Schriftenreihe: | Experimental Oncology |
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| Zitieren: | Crossing chromosomes in pleomorphic sarcoma / A. Batistatou, K. Charalabopoulos // Experimental Oncology. — 2006. — Т. 28, № 3. — С. 248. — Бібліогр.: 6 назв. — англ. |
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248 Experimental Oncology 28, 000–000, 2006 (June)
Atypical mitoses are not unusual in neoplastic cells.
They reflect dysfunction of chromatid dissociation
mechanism during cell division and possibly represent
specific centrosomal alterations involved in carcinogene
sis [1–3]. It was shown that high grade tumors consist
of aneuploid cells, which are genomically unstable and
have high incidence of centrosome amplification [4].
While genomic instability certainly contributes to multi
step carcinogenesis, the role of centrosome amplifica
tion (presence of more than two centrosomes during
mitosis), as event contributing in malignant transforma
tion or chromosomal instability, is not clear at this time.
The causative relation between abnormal number of
centrosomes, multipolar mitoses and development of
cancer cell was suggested by Boveri at the beginning
of 20th century. Today, there is emerging evidence that
centrosome aberrations should be analyzed, based
on cellular context where they occur, since they can
also be detected in nonmalignant cells [4, 5]. Study
of molecular basis of normal centrosome duplication
and dysfunction of this process with oncogenic stimuli
is popular field of modern research.
Furthermore, neoplastic cell mitoses are back in
the center of anticancer research, since new genera
tions of drugs targeting mitosis were developed [6].
Centrosomal amplification can lead to the assembly of
multipolar spindles, which create spectacular multipolar
mitotic figures. Herein, we present a case of 55yearold
man, who had giant cell malignant fibrous histiocytoma
(undifferentiated pleomorphic sarcoma with giant cells,
according to WHO Classification), in the retroperitoneal
region. During microscopic analysis abundant atypical
mitoses were observed. One such mitosis is depicted
in the Figure. It has close resemblance to Cross.
Figure. Crossing chromosomes in atypical mitosis (hematoxylin
and eosin stain, X 1000)
REFERENCES
1. Batistatou A. Mitoses and cancer. Med Hypotheses
2004; 63: 281–2.
2. Golias Ch, Charalabopoulos A, Charalabopoulos K. Cell
proliferation and cell cycle control: a mini review. Int J Clin
Pract 2004; 58: 1134–41.
3. Spankuch-Schmitt B, Bereiter-Hahn J, Kaufmann M,
Strebhardt K. Effect of RNA silencing of Polo-like kinase-1
(PLK-1) on apoptosis and spindle formation in human cancer
cells. J Natl Cancer Inst 2002; 94: 1863–77.
4. Sluder G, Nordberg J. The good, the bad and the ugly:
the practical consequences of centrosome amplification. Curr
Opinion Cell Biol 2004; 16: 49–54.
5. Duensing S. A tentative classification of centrosome
abnormalities. Cell Biol Int 2005; 29: 352–9.
6. Garber K. Divide and conquer: new generation of drugs
targets mitosis. J Natl Cancer Inst 2005; 97: 874–6.
CRoSSiNg ChRomoSomES iN plEomoRphiC SaRComa
A. Batistatou1, *, K. Charalabopoulos2
1Department of Pathology, University of Ioannina Medical School, Ioannina, Greece
2Department of Physiology, Clinical Unit, University of Ioannina Medical School, Ioannina, Greece
Received: March 15, 2006
*Correspondence: E-mail: abatista@cc.uoi.gr
Exp Oncol 2006
28, 3, 248
Copyright © Experimental Oncology, 2006
Перекрещивающиеся хромосомы в случае
Плейоморфной саркомы.
А. Батистату, К. Чаралабопулос
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irk-123456789-1375742018-06-18T03:05:51Z Crossing chromosomes in pleomorphic sarcoma Batistatou, A. Charalabopoulos, K. Short communications 2006 Article Crossing chromosomes in pleomorphic sarcoma / A. Batistatou, K. Charalabopoulos // Experimental Oncology. — 2006. — Т. 28, № 3. — С. 248. — Бібліогр.: 6 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137574 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Batistatou, A. Charalabopoulos, K. Crossing chromosomes in pleomorphic sarcoma Experimental Oncology |
| format |
Article |
| author |
Batistatou, A. Charalabopoulos, K. |
| author_facet |
Batistatou, A. Charalabopoulos, K. |
| author_sort |
Batistatou, A. |
| title |
Crossing chromosomes in pleomorphic sarcoma |
| title_short |
Crossing chromosomes in pleomorphic sarcoma |
| title_full |
Crossing chromosomes in pleomorphic sarcoma |
| title_fullStr |
Crossing chromosomes in pleomorphic sarcoma |
| title_full_unstemmed |
Crossing chromosomes in pleomorphic sarcoma |
| title_sort |
crossing chromosomes in pleomorphic sarcoma |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2006 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137574 |
| citation_txt |
Crossing chromosomes in pleomorphic sarcoma / A. Batistatou, K. Charalabopoulos // Experimental Oncology. — 2006. — Т. 28, № 3. — С. 248. — Бібліогр.: 6 назв. — англ. |
| series |
Experimental Oncology |
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AT batistatoua crossingchromosomesinpleomorphicsarcoma AT charalabopoulosk crossingchromosomesinpleomorphicsarcoma |
| first_indexed |
2025-07-10T02:36:41Z |
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2025-07-10T02:36:41Z |
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1837225744341663744 |