Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification
Among the long-term effects of the Chornobyl disaster the greatest concern of international medical and scientific community is given to the established fact of excess of the spontaneous level of cancer incidence in the exposed population. According to modern concepts, the accumulation of chromosome...
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| Datum: | 2016 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2016
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| Schriftenreihe: | Experimental Oncology |
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| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/137703 |
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| Zitieren: | Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification / E.A. Domina // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 219-223. — Бібліогр.: 46 назв. — англ. |
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irk-123456789-1377032018-06-18T03:06:56Z Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification Domina, E.A. Reviews Among the long-term effects of the Chornobyl disaster the greatest concern of international medical and scientific community is given to the established fact of excess of the spontaneous level of cancer incidence in the exposed population. According to modern concepts, the accumulation of chromosome aberrations, especially in radiosensitive cells, could be potentially oncogenic, and low doses of ionizing radiation could be promoters of the radiation-induced carcinogenesis. The results of our studies have shown that such substances as thymalin, inosine, ascorbic acid, caffeine could modify radiation-induced cytogenetic effects in peripheral blood lymphocytes of healthy individuals and exert protective or sensitizing action dependent on their concentrations, cell radiosensitivity, dose of irradiation, and relative biologic effectiveness of ionizing radiation. This article is part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”. 2016 Article Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification / E.A. Domina // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 219-223. — Бібліогр.: 46 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137703 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Reviews Reviews |
| spellingShingle |
Reviews Reviews Domina, E.A. Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification Experimental Oncology |
| description |
Among the long-term effects of the Chornobyl disaster the greatest concern of international medical and scientific community is given to the established fact of excess of the spontaneous level of cancer incidence in the exposed population. According to modern concepts, the accumulation of chromosome aberrations, especially in radiosensitive cells, could be potentially oncogenic, and low doses of ionizing radiation could be promoters of the radiation-induced carcinogenesis. The results of our studies have shown that such substances as thymalin, inosine, ascorbic acid, caffeine could modify radiation-induced cytogenetic effects in peripheral blood lymphocytes of healthy individuals and exert protective or sensitizing action dependent on their concentrations, cell radiosensitivity, dose of irradiation, and relative biologic effectiveness of ionizing radiation. This article is part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”. |
| format |
Article |
| author |
Domina, E.A. |
| author_facet |
Domina, E.A. |
| author_sort |
Domina, E.A. |
| title |
Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification |
| title_short |
Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification |
| title_full |
Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification |
| title_fullStr |
Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification |
| title_full_unstemmed |
Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification |
| title_sort |
chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2016 |
| topic_facet |
Reviews |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137703 |
| citation_txt |
Chornobyl catastrophe: cytogenetic effects of low dose ionizing radiation and their modification / E.A. Domina // Experimental Oncology. — 2016 — Т. 38, № 4. — С. 219-223. — Бібліогр.: 46 назв. — англ. |
| series |
Experimental Oncology |
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2025-07-10T04:20:21Z |
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2025-07-10T04:20:21Z |
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