Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X
Saved in:
| Date: | 2006 |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2006
|
| Series: | Experimental Oncology |
| Subjects: | |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/137928 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X / V.G. Nikolaev // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 328. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
irk-123456789-137928 |
|---|---|
| record_format |
dspace |
| fulltext |
328 Experimental Oncology 28, 328, 2006 (December)
This monograph is one among not numerous pub-
lications in subdiscipline of molecular oncology. It in-
cludes materials of Ukrainian and foreign investigators
from the leading scientific centers. Substantial place
in this book is occupied by information about the role
of superoxide radical-anions and nitric oxide in the
processes of proliferation, differentiation and apop-
tosis. The sources of oxygen radical generation in cell
compartments of mitochondrial respiratory chain and
endoplasmic reticulum are characterized in details,
and mechanisms of nitric oxide synthesis initiation
in cells of different organs and tissues are analyzed.
Authors have summarized a fundamental volume of
long-term studies of the roles of reactive oxygen spe-
cies and nitric oxide in mechanisms of carcinogenesis
and anticarcinogenesis, and as a result of this work
they established the program of oncologic disease
prevention, based on oxidative damage management
in mitochondria and other cell organelles. For the first
time a number of molecular markers of cell structure
oxidation such as nitric oxide radicals, NO-Hb, oxygen
radicals, 8-oxodGu and others, that can be useful in
oncologic clinics for neoplasia prognosis, estima-
tion of individual sensitivity, monitoring of treatment
efficiency using regulatory approaches for reactive
oxygen species and nitric oxide levels in cells was de-
termined. Reviewed monograph is of general character
introduction and analysis of sophisticated interaction
between superoxide radical-anions and nitric oxide
radicals in regulatory signaling network of the cells
that open consequent ways for solving problems of
clinical oncology, particularly the increase of treatment
efficacy and prognosis. Signaling cascades regulating
reactive oxygen species and nitric oxide content in dif-
ferent cells and initiating programs of cell response on
damage were analyzed. It was proved that during inter-
action between superoxyde radical-anions, hydroxyl
radical, nitric oxide and components of electron trans-
fer chains on cell membranes and regulatory network
their functions are modified. Molecular mechanisms of
participation of reactive oxygen species and reactive
form of nitric oxide in induction of genome instability
through damage of guanine in DNA structure during
chemical and radiation induced carcinogenesis were
determined. The goal of this work is that in clinical and
experimental studies authors employed a wide range
of modern biophysical, biochemical and oncological
methods, particularly Electron Spin Resonance and
Spin Traps technique. It should be emphasized, that
authors are pioneers in application of this advanced
method for solving problems of oncology and radiobio-
logy. There is no necessity to announce all chapters
of the monograph, but the conception of stated mate-
rial and significance of reactive oxygen species and
nitric oxide for oncology should be underlined. Book
is illustrated with up-dated schemes of synthesis and
generation of nitric oxide, superoxide radical-anions
in electron transferring chains on mitochondrial mem-
branes and microsomes and their interaction with cell
components.
This book raises a lot of questions, which may
stimulate scientific activity among professionals of dif-
ferent profiles: oncologists, biophysics, biochemists,
pathophysiologists, and pharmacologists.
Review on BooK “Radical foRms of oxygen and nitRic
oxide in tumouRogenesis”
By a.P. BuRlaKa and e.P. sidoRiK, “scientific BooK” PRoject,
Kyiv: nauKova dumKa, 2006, 228 p. (in uKRainian)
isBn: 966-00-0463-x
Professor V.G. Nikolaev
Department of physical and chemical methods of sorption detoxication, R.E. Kavetsky Institute of
Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv, Ukraine
Received: October 5, 2006.
Correspondence: Fax: (044) 257-9055
Exp Oncol 2006
28, 4, 328
|
| spelling |
irk-123456789-1379282018-06-18T03:10:41Z Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X Short communications 2006 Article Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X / V.G. Nikolaev // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 328. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137928 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Short communications Short communications |
| spellingShingle |
Short communications Short communications Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X Experimental Oncology |
| format |
Article |
| title |
Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X |
| title_short |
Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X |
| title_full |
Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X |
| title_fullStr |
Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X |
| title_full_unstemmed |
Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X |
| title_sort |
review on book “radical forms of oxygen and nitric oxide in tumourogenesis” by a.p. burlaka and e.p. sidorik, “scientific book” project, kyiv: naukova dumka, 2006, 228 p. (in ukrainian) isbn: 966-00-0463-x |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2006 |
| topic_facet |
Short communications |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/137928 |
| citation_txt |
Review on BOOK “Radical forms of oxygen and nitric oxide in tumourogenesis” by A.P. Burlaka and E.P. Sidorik, “Scientific book” Project, Kyiv: Naukova Dumka, 2006, 228 p. (in Ukrainian) ISBN: 966-00-0463-X / V.G. Nikolaev // Experimental Oncology. — 2006. — Т. 28, № 4. — С. 328. — англ. |
| series |
Experimental Oncology |
| first_indexed |
2025-07-10T04:45:14Z |
| last_indexed |
2025-07-10T04:45:14Z |
| _version_ |
1837233828820680704 |