Daniil F. Gluzman (on the 80th birth anniversary)
In June 2016, Professor Daniil Fishelevich Gluzman, well-known Ukrainian oncohematologist, celebrates his 80th anniversary.
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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| Schriftenreihe: | Experimental Oncology |
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irk-123456789-1379972018-06-18T03:03:54Z Daniil F. Gluzman (on the 80th birth anniversary) Chronicle In June 2016, Professor Daniil Fishelevich Gluzman, well-known Ukrainian oncohematologist, celebrates his 80th anniversary. 2016 Article Daniil F. Gluzman (on the 80th birth anniversary) // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 141-143. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/137997 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Chronicle Chronicle Daniil F. Gluzman (on the 80th birth anniversary) Experimental Oncology |
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In June 2016, Professor Daniil Fishelevich Gluzman, well-known Ukrainian oncohematologist, celebrates his 80th anniversary. |
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Article |
| title |
Daniil F. Gluzman (on the 80th birth anniversary) |
| title_short |
Daniil F. Gluzman (on the 80th birth anniversary) |
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Daniil F. Gluzman (on the 80th birth anniversary) |
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Daniil F. Gluzman (on the 80th birth anniversary) |
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Daniil F. Gluzman (on the 80th birth anniversary) |
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daniil f. gluzman (on the 80th birth anniversary) |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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2016 |
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Chronicle |
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http://dspace.nbuv.gov.ua/handle/123456789/137997 |
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Daniil F. Gluzman (on the 80th birth anniversary) // Experimental Oncology. — 2016 — Т. 38, № 2. — С. 141-143. — англ. |
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Experimental Oncology |
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2025-07-10T02:46:34Z |
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2025-07-10T02:46:34Z |
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Experimental Oncology ��� �������� ���� ���ne���� �������� ���� ���ne� ���ne� ���
DANIIL F. GLUZMAN
(ON THE 80TH BIRTH ANNIVERSARY)
In June 2016, Professor Daniil Fishelevich Gluzman, well-known Ukrainian oncohematologist, celebrates his 80th anniversary.
D.F. Gl�zman grad�ated from Bogomolets Kyiv
Medical Instit�te in �9�� and started his medical
career as the pediatric physician in Ovr�ch Pediatric
Hospital� Zhytomyr region. Since �9��� he started his
research activity as the research fellow at the Instit�te
of Experimental and Clinical Oncology �nowadays —
R.E. Kavetsky Instit�te of Experimental Pathology�
Oncology and Radiobiology of the National Aca
demy of Sciences of Ukraine� — the Instit�te where
he worked for many years �nder the s�pervision of its
first director� the famo�s Ukrainian oncologist and
pathophysiologist Academician R.E. Kavetsky� the
Instit�te where Daniil Fishelevich was inspired from the
first days by the creative atmosphere of scientific work�
the Instit�te to which Daniil Fishelevich has been com
mitted himself for life. His first research started at the
Department of Le�kemogenesis Mechanisms headed
by Academician Z.A. B�tenko� where Dr. D.F. Gl�zman
�pheld his thesis for candidate’s degree in �9�7� and
doctoral thesis in �975. And in �9��� D.F. Gl�zman�
by then — Doctor of Medicine and Professor� headed
the Laboratory of Cytochemistry and Imm�nocyto
chemistry �nowadays — Department of Oncohemato
logy� adhering to the ideas and traditions that were set
forth by his famo�s teachers.
Prof. D.F. Gl�zman is well known by his pioneering
research in developing the cytochemical methods for
st�dying the progenitor cells in vario�s hematopoietic
lineages. His pivotal st�dies on identification of the he
matopoietic stem cells in the yolk sac have been widely
recognized providing the basis for the advanced st�dy
of the relationship between the malignant transforma
tion in ontogenesis and the origin of le�kemias in the
children. Prof. D.F. Gl�zman with his colleag�es has
convincingly demonstrated that hematopoietic pro
genitor cells believed morphologically �nidentifiable
possess the marker cytochemical feat�res inherent
to the mat�re cells of the specified hematopoietic lin
eages. These data were in line with gro�ndbreaking
research on stem cells initiated at o�r Instit�te as early
as in 7�s of XX cent�ry by the leaders of Ukrainian
oncology science Academicians R.E. Kavetsky
and Z.A. B�tenko. In partic�lar� the findings demon
strated by Prof. D.F. Gl�zman represented the theo
retical gro�nds for the �se of cytochemical methods
in delineation of vario�s forms and cytological variants
of ac�te le�kemias res�lting from the transformation
and clonal proliferation of vario�s categories of hema
topoietic progenitor cells. And in fact� the cytochemical
st�dies of blood cells have been widely �sed in diffe
rential diagnosis of vario�s forms of ac�te le�kemias
appearing val�able for their classification. The res�lts
of this research o�tlined in a series of the monographs
“Diagnostic Cytochemistry of Hemoblastoses” ��97��;
“Cytochemistry and Imm�nocytology of Malignant
Lymphoproliferative Diseases” ��9���; “Embryonic
Hemopoiesis and Hemoblastoses in Children” ��9���
are widely q�oted by those engaged in cytochemical
st�dy of blood cells.
In the Department headed by D.F. Gl�zman�
in ��s of XX cent�ry the team of Dr. S.P. Sidorenko
�now corresponding member of the National Academy
of Sciences of Ukraine� and other yo�ng at that time
research fellows being inspired by the hybridome
technology boom prod�ced the firstever monoclo
nals in Ukraine against differentiation and activation
antigens of the cells of h�man hematopoietic and
lymphoid tiss�es. The novel imm�nocytochemical
techniq�es for the detection of the wide array of the
antigens in blast cells in the smears of blood and bone
marrow� fineneedle p�nctates of lymph nodes and
t�mors have been elaborated and improved allowing
for high q�ality and precision of diagnostic examina
tions based on imm�nophenotyping of le�kemic cells.
The theoretical fo�ndations and general principles
of applying cytochemical and imm�nocytochemical
markers in the diagnosis of vario�s forms of le�ke
mia and malignant lymphoma have been elaborated.
F�rthermore� in a series of st�dies the role of lectin
receptors differing in carbohydrate specificity in the
mat�ration of hematopoietic cells of vario�s origins
Exp Oncol ����
��� �� �������
CHRONICLE
��� Experimental Oncology ��� �������� ���� ���ne�
has been el�cidated. The biotinylated neoglicoprotein
probes were �sed in the original st�dies of endo
geno�s lectins in normal and le�kemic hematopoietic
and lymphoid cells.
The practical implementation of the complex
of modified cytomorphological� cytochemical and
imm�nocytochemical techniq�es has been advanta
geo�s for improving the level of diagnosing the ma
lignant t�mors of hematopoietic and lymphoid tiss�es
in Ukraine to meet the req�irements of the �ptodate
classifications �sed in Western co�ntries. The inno
vative theoretical developments of the Department
headed by Prof. D.F. Gl�zman laid the gro�ndwork
for the largescale practical activities in diagnosing
le�kemia and lymphoma among the patients referred
by medical instit�tions from Kyiv and all over Ukraine.
The extensive network connecting the Department
of Imm�nocytochemistry �nowadays — Department
of Oncohematology� and dozens of clinical facilities
all over Ukraine proved to be the effective tool for
assisting the clinicianshematologists in diagnosing
precisely vario�s hematological malignancies. Ann�
ally� diagnostic tests �sing modern technologies are
provided in more than �5�� patients from �� regions
of Ukraine. Of partic�lar note is the assistance pro
vided to the children with cancer pathology. The state
ofthearts in modern diagnosis of le�kemias as well
as the longterm practical experience of the Depart
ment headed by Prof. D.F. Gl�zman were s�mmarized
in the series of monographs comprising “Imm�nocy
tochemistry and Monoclonal Antibodies in Oncohe
matology” ��99��� “Imm�nocytochemical Diagnosis
of Malignant Sero�s Eff�sions” ��99��� “Laboratory
Diagnosis of Oncohematological Diseases” ��99���
“Le�kemia Diagnosis. Atlas and Practical Handbook”
������ becoming the g�idebooks for clinicians
hematologists and the specialists in experimental and
clinical oncohematology in Ukraine. Prof. D.F. Gl�zman
was the first to develop and apply methods for iden
tification of micrometastases and t�mor cells in bone
marrow� lymph nodes� sero�s ex�dates and cerebro
spinal fl�id by applying imm�nocytochemical tech
niq�es and monoclonal antibodies against organ and
tiss�especific� oncofetal� t�morassociated antigens�
cytoskeletal proteins. Act�ally� Prof. D.F. Gl�zman cre
ated the �niq�e school of tho�ght for cytologists and
oncohematologists in Ukraine.
In postChernobyl period� the Department of On
cohematology headed by Prof. D.F. Gl�zman has been
engaged in diagnostic examination of Ukrainian pa
tients s�ffered from the conseq�ences of Chernobyl
catastrophe with the partic�lar foc�s on diagnosing
le�kemias in Chernobyl clean�p workers and the
children from the most affected regions. The res�lts
of the longterm research by D.F. Gl�zman and his
colleag�es have drawn the attention of scientific
comm�nity to the real sit�ation with hematopoietic
malignancies in relation to low doses of radiation. After
Chernobyl� the Reference Laboratory of R.E. Kavetsky
Instit�te has become an internationally known center.
It is of high importance that s�ch research was s�p
ported by the specialists in oncohematology from
many co�ntries. In �99������� the st�dy of le�ke
mias in clean�p workers was performed within the
framework of joint Ukrainian�apanese gro�p on st�dy
of le�kemia and lymphoma. This international labora
tory performed the cytological and imm�nophenotypi
cal st�dy of le�kemias in Chernobyl clean�p workers
and compared their forms and cytological variants
to that occ�rred in Hiroshima and Nagasaki many years
after the atomic bombing. These data were presented
at the Radiation Effects Research Fo�ndation �RERF�
�apan� in �999 and ���� and s�mmarized in a series
of p�blications in international jo�rnals. For many
years� D.F. Gl�zman collaborated as hematologist
with French Center “Children of Chernobyl” providing
expertise in diagnosing the hematological diseases
among the children from the regions of Ukraine con
taminated with radion�clides. Prof. D.F. Gl�zman was
involved in the activity of the international committee
of the expertshematologists set �p for verification
of the diagnoses of oncohematological pathologies
within the framework of the collaborative research
program sponsored by USA. Taking into acco�nt the
high q�ality of diagnosing le�kemias in children� the
Department headed by Prof. D.F. Gl�zman was se
lected as the only team from Ukraine for the project
“My Child Matters” sponsored by SanofiAventis and
International Union Against Cancer in ��������7.
In the setting of this project� the large assistance was
provided for the improvement of diagnosing cancer
and le�kemia in the children of o�r co�ntry.
Prof. D.F. Gl�zman is a scientist of permanent cre
ative endeavor. He p�t forward the novel approach for
st�dying radiationassociated le�kemias� in partic�lar
myelodysplastic syndromes and chronic lymphocytic
le�kemia in postChernobyl setting. Recently� the
findings on radiationassociated le�kemias have been
s�mmarized in the collective monograph “Ionizing Ra
diation and Oncohematological Diseases” ������ Aca
demician V.F. Chekh�n and Professor D.F. Gl�zman�
eds.� commemorating ��th anniversary of Chernobyl
catastrophe. Based on the comprehensive analysis
of malignantly transformed le�kemic cells� the novel
approaches to classification of hemoblastoses and
models of hematopoiesis are �nder way.
Prof. D.F. Gl�zman a�thored �� monographs and
more than �5� scientific papers on vario�s aspects
of oncology and hematology� made n�mero�s presen
tations and reports aro�nd the world. He has s�pervised
� doctoral and �5 Ph.D. theses. Prof. D.F. Gl�zman
dedicates a lot of time to p�blishing activities. For
many years Prof. D.F. Gl�zman is Associate Editor �now
Chairman of the Editorial Board� of the international
jo�rnal “Experimental Oncology” and Dep�ty Editorin
Chief of the jo�rnal “Oncology”. It may be said witho�t
exaggeration that not only the iss�es of the jo�rnals
b�t many other p�blications of o�r Instit�te have been
edited thoro�ghly by s�ch a q�alified specialist as Daniil
Fishelevich. Prof. D.F. Gl�zman is also member of the
Experimental Oncology ��� �������� ���� ���ne���� �������� ���� ���ne� ���ne� ���
Editorial Board of jo�rnals “Hematology and Transf�sio
logy”� “Laboratory Diagnosis”� Member of Ukrainian
Society of Hematologists� Ukrainian Society of Oncolo
gists� Associate Member of the International Network
of Cancer Treatment and Research �INCTR�.
Prof. D.F. Gl�zman combines his research activity
with tremendo�s practical and organizational work
aimed at organization of highly q�alified labora
tory assistance in diagnosing patients in Ukraine
with pathologies of hematopoietic system. A series
of booklets entitled “Seminars in Hematopathology”
��5 iss�es in total� initiated by Prof. D.F. Gl�zman and
his colleag�es highlights the recent achievements and
novelties in diagnosing oncohematological diseases.
As a good tradition� the ann�al scientificandmetho
dological seminars on the �rgent problems of cyto
chemistry and imm�nocytology of hemoblastoses
organized by Department of Oncohematology gather
dozens of specialists in hematology and laboratory.
The recent monographs “Diagnostic Oncohemato
logy” ������ and “Modern methods of laboratory
diagnosis of oncohematological diseases” ������ give
a big boost for the improvement of skills of Ukrainian
specialists in hematology.
Prof. D.F. Gl�zman received many honors d�ring
his long career. He is the Honored Master of Science
and Technology of Ukraine. In ����� D.F. Gl�zman
was among the first scientists awarded the memo
rial R.E. Kavetsky Prize of the National Academy
of Sciences of Ukraine for the series of scientific works
“Novel approaches and technologies in diagnosis
and treatment of cancer”. Recently� D.F. Gl�zman
has been among the team awarded the State Prize
of Ukraine in Science and Technology for the series
of works “Monoclonal and recombinant antibodies for
experimental biology� medicine and veterinary” ����5�.
The prominent professional skills of Daniil Fishe
levich are accompanied by his o�tstanding personal
traits. It is not too m�ch to say that he stim�lates and
inspires the dozens of scientists who work with him
over the years. We all appreciate his passion� his
drive� and his willingness to stand �p and fight for
what he believes.
The administration and the staff of R.E. Kavetsky
Instit�te of Experimental Pathology� Oncology and
Radiobiology of the National Academy of Sciences
of Ukraine� Editorial Board� all his colleag�es have
a great pleas�re to congrat�late Prof. D.F. Gl�zman
on the occasion of his ��th birthday and to wish him
good health� inexha�stible energy� long years of f�rther
activity as a scientist and new scientific achievements.
Scientific Council and scientists
of R.E. Kavetsky Institute of Experimental
Pathology, Oncology and Radiobiology
of the National Academy of Sciences of Ukraine
Editorial Boards of “Experimental Oncology”
and “Oncology” journals
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