Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results

Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results

Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal...

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Date:2010
Main Authors: Piatrouskaya, N.A., Kharuzhyk, S.A., Vozmitel, M.A., Mazurenko, A.N., Istomin, Y.P.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2010
Series:Experimental Oncology
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Original contributions
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/138601
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ.

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spelling irk-123456789-1386012018-06-20T03:07:17Z Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results Piatrouskaya, N.A. Kharuzhyk, S.A. Vozmitel, M.A. Mazurenko, A.N. Istomin, Y.P. Original contributions Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal inoculation, eighteen tumor-bearing animals were divided into three groups and undergone intraperitoneal photodynamic therapy and/or antiangiogenic therapy. Assessment of the tumor posttreatment changes was performed using a method of vital staining with Evans blue, MRI-monitoring and morphologic investigation. Results: Percentage of necrosis in disseminated tumors of animals undergone combination therapy significantly higher then after each of the methods alone and achieved 89.46% vs 41.47% after antiangiogenic therapy and 69.73% after photodynamic therapy. Contrast-enhanced MRI showed entirely necrotic tumor nodes in rats undergone the combination therapy. Morphologic study confirmed that tumor response after combination therapy was characterized by maximal spread of necrotic and inflammatory changes in tumor. Conclusion: Preliminary results demonstrate enhance of the treatment outcome after combination of antiangiogenic and intraperitoneal photodynamic therapies for peritoneal carcinomatosis in rats. 2010 Article Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138601 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
Experimental Oncology
description Aim: To create adequate orthotopic model of peritoneal carcinomatosis in rats using a transplantable rat tumor M-1 sarcoma, to assess the early tumor response after intraperitoneal photodynamic and/or antiangiogenic therapy for peritoneal carcinomatosis. Methods: In 14–18 days after intraperitoneal inoculation, eighteen tumor-bearing animals were divided into three groups and undergone intraperitoneal photodynamic therapy and/or antiangiogenic therapy. Assessment of the tumor posttreatment changes was performed using a method of vital staining with Evans blue, MRI-monitoring and morphologic investigation. Results: Percentage of necrosis in disseminated tumors of animals undergone combination therapy significantly higher then after each of the methods alone and achieved 89.46% vs 41.47% after antiangiogenic therapy and 69.73% after photodynamic therapy. Contrast-enhanced MRI showed entirely necrotic tumor nodes in rats undergone the combination therapy. Morphologic study confirmed that tumor response after combination therapy was characterized by maximal spread of necrotic and inflammatory changes in tumor. Conclusion: Preliminary results demonstrate enhance of the treatment outcome after combination of antiangiogenic and intraperitoneal photodynamic therapies for peritoneal carcinomatosis in rats.
format Article
author Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
author_facet Piatrouskaya, N.A.
Kharuzhyk, S.A.
Vozmitel, M.A.
Mazurenko, A.N.
Istomin, Y.P.
author_sort Piatrouskaya, N.A.
title Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_short Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_full Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_fullStr Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_full_unstemmed Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
title_sort experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2010
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138601
citation_txt Experimental study of antiangiogenic and photodynamic therapies combination for treatment of peritoneal carcinomatosis: preliminary results / N.A. Piatrouskaya, S.A. Kharuzhyk, M.A. Vozmitel, A.N. Mazurenko, Y.P. Istomin // Experimental Oncology. — 2010. — Т. 32, № 2. — С. 100-103. — Бібліогр.: 14 назв. — англ.
series Experimental Oncology
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AT kharuzhyksa experimentalstudyofantiangiogenicandphotodynamictherapiescombinationfortreatmentofperitonealcarcinomatosispreliminaryresults
AT vozmitelma experimentalstudyofantiangiogenicandphotodynamictherapiescombinationfortreatmentofperitonealcarcinomatosispreliminaryresults
AT mazurenkoan experimentalstudyofantiangiogenicandphotodynamictherapiescombinationfortreatmentofperitonealcarcinomatosispreliminaryresults
AT istominyp experimentalstudyofantiangiogenicandphotodynamictherapiescombinationfortreatmentofperitonealcarcinomatosispreliminaryresults
first_indexed 2025-07-10T06:09:54Z
last_indexed 2025-07-10T06:09:54Z
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