Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line
Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of d...
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| Datum: | 2011 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Schriftenreihe: | Experimental Oncology |
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| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/138616 |
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| Zitieren: | Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. |
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irk-123456789-1386162018-06-20T03:08:20Z Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. Original contributions Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin. 2011 Article Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138616 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| topic |
Original contributions Original contributions |
| spellingShingle |
Original contributions Original contributions Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line Experimental Oncology |
| description |
Aim: To study distribution and accumulation of liposomal form of doxorubicin in human breast cancer cells of MCF-7 line and Dox-resistant subline MCF-7/Dox. Methods: High performance liquid chromatography and laser confocal microscopy were used. Results: It has been shown that conventional form of doxorubicin was more efficiently delivered to the MCF-7 cells already after 30 min of incubation amounting to its maximum concentration after 4 h. MCF-7/Dox cells are characterized by lower doxorubicin accumulation rate compared with parental cells. The quantity of accumulated liposomal form of doxorubicin is high in MCF-7 cells, and, what is important, Dox-resistant cells accumulated higher levels of liposomal form of doxorubicin than its conventional form. Conclusion: It has been shown that intracellular distribution and accumulation of liposomal forms of doxorubicin in parental and Dox-resistant MCF-7 cells differs from that of conventional doxorubicin. |
| format |
Article |
| author |
Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
| author_facet |
Rusetskaya, N.V. Khariton, N. Yurchenko, O.V. Chekhun, V.F. |
| author_sort |
Rusetskaya, N.V. |
| title |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_short |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_full |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_fullStr |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_full_unstemmed |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line |
| title_sort |
distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of mcf-7 line |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2011 |
| topic_facet |
Original contributions |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/138616 |
| citation_txt |
Distribution and accumulation of liposomal form of doxorubicin in breast cancer cells of MCF-7 line / N.V. Rusetskaya, N. Khariton, O.V. Yurchenko, V.F. Chekhun // Experimental Oncology. — 2011. — Т. 33, № 2. — С. 78-82. — Бібліогр.: 22 назв. — англ. |
| series |
Experimental Oncology |
| work_keys_str_mv |
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| first_indexed |
2025-07-10T06:11:20Z |
| last_indexed |
2025-07-10T06:11:20Z |
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