Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model

Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model

Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell...

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Datum:2012
Hauptverfasser: Rico, M.J., Rozados, V.R., Mainetti, L.E., Zacarias Fluck, M.F., Matar, P., Scharovsky, O.G.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
Schriftenreihe:Experimental Oncology
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Original contributions
Online Zugang:http://dspace.nbuv.gov.ua/handle/123456789/138719
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Zitieren:Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model / M.J. Rico, V.R. Rozados, L.E. Mainetti, M.F. Zacarias Fluck, P. Matar, O.G. Scharovsky // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 38-42. — Бібліогр.: 36 назв. — англ.

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spelling irk-123456789-1387192018-06-20T03:04:59Z Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model Rico, M.J. Rozados, V.R. Mainetti, L.E. Zacarias Fluck, M.F. Matar, P. Scharovsky, O.G. Original contributions Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells. 2012 Article Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model / M.J. Rico, V.R. Rozados, L.E. Mainetti, M.F. Zacarias Fluck, P. Matar, O.G. Scharovsky // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 38-42. — Бібліогр.: 36 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/138719 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Rico, M.J.
Rozados, V.R.
Mainetti, L.E.
Zacarias Fluck, M.F.
Matar, P.
Scharovsky, O.G.
Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
Experimental Oncology
description Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by low dose Cy, of T regulatory (Treg) and natural killer T (NKT) I cells, two cell populations of the innate immune response with opposing effects on the tumors, in a rat B cell lymphoma model. Methods: Inbred e rats were challenged s.c. with L-TACB lymphoma and on day 14 animals were distributed in two groups. Treated: injected i.p. with cyclophosphamide (10mg/kg of body weight) and Control: injected i.p. with saline. Blood samples were taken from days 0 to 21 and the percentage of T regulatory and natural killer T I cells were determined by flow cytometry. Results: We found that the increase of natural and inducible T regulatory cells of peripheral blood achieved during tumor growth was significantly downregulated by cyclophosphamide. On the contrary, natural killer T I cells were not modulated by the treatment. Conclusion: The antimetastatic effect of a single low dose of Cy would be due, at least in part, to downregulation of natural and inducible T regulatory cells.
format Article
author Rico, M.J.
Rozados, V.R.
Mainetti, L.E.
Zacarias Fluck, M.F.
Matar, P.
Scharovsky, O.G.
author_facet Rico, M.J.
Rozados, V.R.
Mainetti, L.E.
Zacarias Fluck, M.F.
Matar, P.
Scharovsky, O.G.
author_sort Rico, M.J.
title Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
title_short Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
title_full Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
title_fullStr Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
title_full_unstemmed Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model
title_sort regulatory t cells but not nkt i cells are modulated by a single low-dose cyclophosphamide in a b cell lymphoma tumor-model
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2012
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/138719
citation_txt Regulatory T cells but not NKT I cells are modulated by a single low-dose Cyclophosphamide in a B cell lymphoma tumor-model / M.J. Rico, V.R. Rozados, L.E. Mainetti, M.F. Zacarias Fluck, P. Matar, O.G. Scharovsky // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 38-42. — Бібліогр.: 36 назв. — англ.
series Experimental Oncology
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