Vitamin C: attenuating effect on growth and proliferation in systemic malignancies
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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| Zitieren: | Vitamin C: attenuating effect on growth and proliferation in systemic malignancies / S. Kapoor // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 72. — Бібліогр.: 10 назв. — англ. |
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irk-123456789-1390782018-06-20T03:11:58Z Vitamin C: attenuating effect on growth and proliferation in systemic malignancies Kapoor, S. Letter to editor 2013 Article Vitamin C: attenuating effect on growth and proliferation in systemic malignancies / S. Kapoor // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 72. — Бібліогр.: 10 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139078 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Letter to editor Letter to editor Kapoor, S. Vitamin C: attenuating effect on growth and proliferation in systemic malignancies Experimental Oncology |
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Article |
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Kapoor, S. |
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Kapoor, S. |
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Kapoor, S. |
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Vitamin C: attenuating effect on growth and proliferation in systemic malignancies |
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Vitamin C: attenuating effect on growth and proliferation in systemic malignancies |
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Vitamin C: attenuating effect on growth and proliferation in systemic malignancies |
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Vitamin C: attenuating effect on growth and proliferation in systemic malignancies |
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Vitamin C: attenuating effect on growth and proliferation in systemic malignancies |
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vitamin c: attenuating effect on growth and proliferation in systemic malignancies |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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2013 |
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Letter to editor |
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Vitamin C: attenuating effect on growth and proliferation in systemic malignancies / S. Kapoor // Experimental Oncology. — 2013. — Т. 35, № 1. — С. 72. — Бібліогр.: 10 назв. — англ. |
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Experimental Oncology |
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AT kapoors vitamincattenuatingeffectongrowthandproliferationinsystemicmalignancies |
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2025-07-10T07:34:40Z |
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72 Experimental Oncology 35, 72–72, 2013 (March)
VITAMIN C: ATTENUATING EFFECT ON GROWTH
AND PROLIFERATION IN SYSTEMIC MALIGNANCIES
S. Kapoor
Mechanicsville, VA 23111, USA
The recent article by J. Cha et al. provided for highly
interesting reading [1].Vitamin C may attenuate tumor
growth in a number of other systemic malignancies.
Vitamin C has a negative impact on tumor growth
in breast cancers. Similarly it mitigates tumor me-
tastasis. It mediates this effect in part by attenuating
IL-6 levels [2]. Similar effect is seen on VEGF levels. In-
terestingly, intravenous ascorbic acid has been shown
to significantly improve the quality of life in breast can-
cer survivors during chemotherapy [3]. For instance,
symptoms such as depression and nausea are mark-
edly decreased. Enhanced anti-proliferative effects
are seen when vitamin C is administered in conjunction
with agents such as retinoic acid [4]. In one recent
study, the reported synergistic ratio of retinoic acid
and vitamin C was 1.72. Vitamin C also augments the
anti-neoplastic activity of chemotherapeutic agents
such as cisplatin [5]. Similarly it increases the sentivity
of breast cancer cells to agents such as doxorubicin.
Similar effects are seen in gastric malignancies.
Vitamin C tends to augment intra-tumoral apoptosis.
It mediates this effect by down-regulating 14–3–3σ via
a mitochondrial dependent pathway [6]. Part of these
pro-apoptotic effects are also mediated via p38-
MAP kinase-dependent up-regulation of transferrin
receptor [7]. It also increases the Bax/ Bcl-xL ratio.
These effects are dose dependent. Administration
of vitamin C also augments superoxide dismutase
activity. Vitamin C also enhances MHC class I expres-
sion by the cancerous cells [8]. At the same time Fas
(CD95) expression is markedly augmented. As a result
the sensitivity of cancer cells to anti-Fas antibodies
is significantly accentuated.
Similarly, decreased RBC vitamin C levels have
been noted in patients with prostate carcinomas.
In fact, recent studies indicate that vitamin C mark-
edly attenuates tumor growth in hormone refractory
prostatic malignancies [9]. It also has a negative im-
pact on tumor metastasis. Part of these effects are
mediated via VEGF inhibition. At the same time vitamin
C has an inhibitory effect on MMP-9 [10].
The above examples clearly highlight the significant
anti-neoplastic effects of vitamin C.
REFERENCES
1. Cha J, Roomi MW, Ivanov V, et al. Ascorbate depletion
increases growth and metastasis of melanoma cells in vita-
min C deficient mice. Exp Oncol 2011; 33: 226–230.
2. Cha J, Roomi MW, Ivanov V, et al. Ascorbate supple-
mentation inhibits growth and metastasis of B16FO melanoma
and 4T1 breast cancer cells in vitamin C-deficient mice. Int
J Oncol 2013; 42: 55–64.
3. Vollbracht C, Schneider B, Leendert V, et al. Intravenous
vitamin C administration improves quality of life in breast can-
cer patients during chemo-/radiotherapy and aftercare: results
of a retrospective, multicentre, epidemiological cohort study
in Germany. In Vivo 2011; 25: 983–90.
4. Kim KN, Pie JE, Park JH, et al. Retinoic acid and
ascorbic acid act synergistically in inhibiting human breast
cancer cell proliferation. J Nutr Biochem 2006; 17: 454–62.
5. Kurbacher CM, Wagner U, Kolster B, et al. Ascorbic
acid (vitamin C) improves the antineoplastic activity of doxo-
rubicin, cisplatin, and paclitaxel in human breast carcinoma
cells in vitro. Cancer Lett 1996; 103: 183–9.
6. Ha YM, Park MK, Kim HJ, et al. High concentrations
of ascorbic acid induces apoptosis of human gastric cancer cell
by p38-MAP kinase-dependent up-regulation of transferrin
receptor. Cancer Lett 2009; 277: 48–54.
7. Nagappan A, Park KI, Park HS, et al. Vitamin C induces
apoptosis in AGS cells by down-regulation of 14–3-3sigma
via a mitochondrial dependent pathway. Food Chem 2012;
135: 1920–8.
8. Yu Y, Bae S, Kim H, et al. The anti-tumor activity
of vitamin C via the increase of Fas (CD95) and MHC I ex-
pression on human stomach cancer cell line, SNU1. Immune
Netw 2011; 11: 210–5.
9. Surapaneni KM, Ramana V. Erythrocyte ascorbic acid
and plasma vitamin E status in patients with carcinoma of pros-
tate. Ind J Physiol Pharmacol 2007; 51: 199–202.
10. Pollard HB, Levine MA, Eidelman O, Pollard M.
Pharmacological ascorbic acid suppresses syngeneic tumor
growth and metastases in hormone-refractory prostate cancer.
In Vivo 2010; 24: 249–55.
Received: January 25, 2013
Correspondence: E-mail: shailendrakapoor@yahoo.com
Exp Oncol 2013
35, 1,72
LETTER TO THE EDITOR
Copyright © Experimental Oncology, 2013
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