Volodymyr Serhiiovych Mosiienko (1934–2017)
Professor Volodymyr Serhiiovych Mosiienko, the scientist, the leading researcher, Doctor of Medicine passed away
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| Дата: | 2017 |
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| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/139251 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Volodymyr Serhiiovych Mosiienko (1934–2017) // Experimental Oncology. — 2017 — Т. 39, № 4. — С. 322. — англ. |
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irk-123456789-1392512019-01-20T21:14:45Z Volodymyr Serhiiovych Mosiienko (1934–2017) Obituary Professor Volodymyr Serhiiovych Mosiienko, the scientist, the leading researcher, Doctor of Medicine passed away 2017 Article Volodymyr Serhiiovych Mosiienko (1934–2017) // Experimental Oncology. — 2017 — Т. 39, № 4. — С. 322. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/139251 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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Obituary Obituary |
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Obituary Obituary Volodymyr Serhiiovych Mosiienko (1934–2017) Experimental Oncology |
| description |
Professor Volodymyr Serhiiovych Mosiienko, the scientist, the leading researcher, Doctor of Medicine passed away |
| format |
Article |
| title |
Volodymyr Serhiiovych Mosiienko (1934–2017) |
| title_short |
Volodymyr Serhiiovych Mosiienko (1934–2017) |
| title_full |
Volodymyr Serhiiovych Mosiienko (1934–2017) |
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Volodymyr Serhiiovych Mosiienko (1934–2017) |
| title_full_unstemmed |
Volodymyr Serhiiovych Mosiienko (1934–2017) |
| title_sort |
volodymyr serhiiovych mosiienko (1934–2017) |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2017 |
| topic_facet |
Obituary |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/139251 |
| citation_txt |
Volodymyr Serhiiovych Mosiienko (1934–2017) // Experimental Oncology. — 2017 — Т. 39, № 4. — С. 322. — англ. |
| series |
Experimental Oncology |
| first_indexed |
2025-07-10T07:10:35Z |
| last_indexed |
2025-07-10T07:10:35Z |
| _version_ |
1837242975021694976 |
| fulltext |
322 Experimental Oncology 39, 1–322, 2017 (December)
Volodymyr SerhiioVych moSiienko
(1934–2017)
Professor Volodymyr Serhiiovych Mosiienko, the scientist, the leading researcher, Doctor of Medicine passed away
V o l o d y m y r M o -
si ienko was born
o n Fe b r u a r y 2 3 ,
1934 in Zinkiv village
Poltava region in the
fa mily of the peas-
ants. Upon graduat-
ing from the second-
ary school, he stud-
ied at the general
medical department
of O.O. Bogomo-
lets Kyiv Medical
Institute. As a quali-
fied M.D., Dr. Mo-
s i i e n k o w o r k e d
as a general practitioner for two years. Having heard
the news that the research oncological institute was
to set up in Kyiv, Dr. Mosiienko decided to take the path
of studies in such a difficult and intriguing field. Dr. Mo-
siienko started his career of researcher as the post-
graduate under the supervision of Prof. R.E. Kavetsky,
the famous Ukrainian scientist. In 1965, Dr. Mosiienko
defended his PhD thesis “Development of the method
for pelvic perfusion and its use for the treatment
of the experimental malignant tumors”. At that time,
the regional perfusion was considered as one of the
promising approaches for cancer thera py. And later
on, Dr. Mosiienko applied successfully the method
of the regional perfusion in the clinics.
Dr. Mosiienko has contributed much into the
research in the field of pharmacodynamics and
pharmacokinetics of anticancer drugs. The study
of oxygen metabolism, the structured water, and
blood microcirculation in the healthy and malignant
tissues were among the fields of his scientific interests.
He has developed the novel approaches for the use
of antihypoxants, normo- and hypobaric hypoxia and
cryogenic surgery aimed at increasing the efficacy
of cancer treatment.
In 1973, Dr. Mosiienko defended his doctoral thesis
“Regional perfusion in the treatment of malignan-
cies (experimental-and-clinical study)”. Academi-
cian R.E. Kavetsky was the research adviser of both
his PhD and doctoral theses.
Dr. Mosiienko devoted considerable efforts
to elucidate the role of oxygen and free radicals in the
development of tumor. In particular, he studied the ef-
fects of the increased or decreased oxygen pressure
on tumor growth. Dr. Mosiienko explored how to use
the reactive oxygen species both alone and in complex
with cytostatics for cancer treatment. He suggested
that the hypoxic state of the tissues in tumor-bearing
host represents the adaptive response contributing
to increasing survival of cancer patients. Therefore,
contrary to the wide-spread belief that hypoxic treat-
ment is much like “drive out fire with fire”, Dr. Mosiienko
put forward the idea that hypoxic treatment in fact
should be considered as the placement of the host
into more adequate setting approaching the patient
to the “physiological rest state” sparing the energy
resources and deteriorating the environment for tumor
cell growth.
In recent years, Dr. Mosiienko became enthusi-
astic in developing the novel research area — study
of nanoparticles as the probable innovative approach
for cancer treatment. He obtained important results
in experiments with silicon oxide nanoparticles and
fullerenes suggesting the original approaches in the-
rapy of cancer patients.
Dr. Mosiienko is coauthor of the development
of the domestic immunomodulator Blasten. The drug
is regis tered in Ukraine and applied in the clinical set-
tings. Dr. Mosiienko also was engaged in the studies
aimed at improving the efficacy of anticancer vaccines.
Dr. Mosiienko authored more than 200 scientific
papers and 4 monographs. He has 10 patents for his
inventions. He supervised seven completed PhD the-
ses. In his last monographs “Integral Approach towards
Therapy of Neoplastic Diseases” (2009) and “Cancer:
Path into Unknown, Disappointments and Hopes”
(2010), Dr. Mosiienko attempted to consider cancer
problem in the light of the complex interrelationships
in the “host — tumor — environment” triad. In this view,
the author suggested and substantiated the novel ap-
proach to cancer treatment that he called as integral
(adaptive) therapy. Unfortunately, the untimely death
prevented him from finishing these studies.
Dr. Mosiienko was generous and modest re-
sponding to the needs of others. The bright memory
of Volodymyr Serhiiovych Mosiienko will live forever
in the hearts of all who knew him.
Administration and team
of R.E. Kavetsky Institute of Experimental
Pathology, Oncology and Radiobiology
of the NAS of Ukraine
Exp Oncol 2017
39, 4, 322
oBiTUAry
Copyright © Experimental Oncology, 2017
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