CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome

CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome

Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Datum:2015
Hauptverfasser: Osinsky, S., Kovelskaya, A., Bubnovskaya, L., Osinsky, D., Merentsev, S.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
Schriftenreihe:Experimental Oncology
Schlagworte:
Original contributions
Online Zugang:http://dspace.nbuv.gov.ua/handle/123456789/145455
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, A. Kovelskaya, L. Bubnovskaya, D. Osinsky, S. Merentsev // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 48-52. — Бібліогр.: 27 назв. — англ.

Institution

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-145455
record_format dspace
fulltext
spelling irk-123456789-1454552019-01-22T01:23:55Z CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome Osinsky, S. Kovelskaya, A. Bubnovskaya, L. Osinsky, D. Merentsev, S. Original contributions Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45RO-positive T lymphocytes in BM were detected using immunocytochemistry. All patients were thoroughly informed about the study that was approved by the local ethics committee. Statistical analyses were done using NCSS2000/PASS2000 and Prism, version 4.03 software packages. Results: It was detected that 80.5 and 81.3% of patients had CD8- and CD45RO-positive T cells in BM, respectively. When DTCs were detected in BM, the number of patients with CD8-and CD45RO-positive T cells in BM were 86.1 and 84.4%, respectively. It was also determined that the number of patients with DTCs in BM with categories M0 and M1 and with CD8- and CD45RO-positive T cells in BM were 86.2 and 85.7%, 85.7 and 80.0%, respectively. The association between DTCs in BM and presence of CD8 and CD45RO T cells lymphocytes in BM was not found. At the same time it was shown the association between presence of CD8 and CD45RO T lymphocytes and survival. The presence of CD8- and CD45RO-positive T cells in BM were accompanied with significantly longer overall survival of patients compared to that of patients without CD8- and CD45RO-positive T cells in BM. Conclusion: Patients with the presence of CD8- and CD45RO-posi­tive T cells in BM demonstrated better survival of GC patients than those with the absence of these cells in BM. It may be suggested that tumor cells in BM are controlled in a dormant state by T cells in BM, in particular by CD8-positive T cells. Key Words: CD8 T lymphocytes, CD45RO T lymphocytes, bone marrow, disseminated tumor cells, tumor hypoxia, survival. 2015 Article CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, A. Kovelskaya, L. Bubnovskaya, D. Osinsky, S. Merentsev // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 48-52. — Бібліогр.: 27 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145455 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
Experimental Oncology
description Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45RO-positive T lymphocytes in BM were detected using immunocytochemistry. All patients were thoroughly informed about the study that was approved by the local ethics committee. Statistical analyses were done using NCSS2000/PASS2000 and Prism, version 4.03 software packages. Results: It was detected that 80.5 and 81.3% of patients had CD8- and CD45RO-positive T cells in BM, respectively. When DTCs were detected in BM, the number of patients with CD8-and CD45RO-positive T cells in BM were 86.1 and 84.4%, respectively. It was also determined that the number of patients with DTCs in BM with categories M0 and M1 and with CD8- and CD45RO-positive T cells in BM were 86.2 and 85.7%, 85.7 and 80.0%, respectively. The association between DTCs in BM and presence of CD8 and CD45RO T cells lymphocytes in BM was not found. At the same time it was shown the association between presence of CD8 and CD45RO T lymphocytes and survival. The presence of CD8- and CD45RO-positive T cells in BM were accompanied with significantly longer overall survival of patients compared to that of patients without CD8- and CD45RO-positive T cells in BM. Conclusion: Patients with the presence of CD8- and CD45RO-posi­tive T cells in BM demonstrated better survival of GC patients than those with the absence of these cells in BM. It may be suggested that tumor cells in BM are controlled in a dormant state by T cells in BM, in particular by CD8-positive T cells. Key Words: CD8 T lymphocytes, CD45RO T lymphocytes, bone marrow, disseminated tumor cells, tumor hypoxia, survival.
format Article
author Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
author_facet Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
author_sort Osinsky, S.
title CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_short CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_full CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_fullStr CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_full_unstemmed CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_sort cd8 and cd45ro t lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2015
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145455
citation_txt CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, A. Kovelskaya, L. Bubnovskaya, D. Osinsky, S. Merentsev // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 48-52. — Бібліогр.: 27 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT osinskys cd8andcd45rotlymphocytesinbonemarrowofgastriccancerpatientscorrelationwithdisseminatedtumorcellsanddiseaseoutcome
AT kovelskayaa cd8andcd45rotlymphocytesinbonemarrowofgastriccancerpatientscorrelationwithdisseminatedtumorcellsanddiseaseoutcome
AT bubnovskayal cd8andcd45rotlymphocytesinbonemarrowofgastriccancerpatientscorrelationwithdisseminatedtumorcellsanddiseaseoutcome
AT osinskyd cd8andcd45rotlymphocytesinbonemarrowofgastriccancerpatientscorrelationwithdisseminatedtumorcellsanddiseaseoutcome
AT merentsevs cd8andcd45rotlymphocytesinbonemarrowofgastriccancerpatientscorrelationwithdisseminatedtumorcellsanddiseaseoutcome
first_indexed 2025-07-10T21:45:45Z
last_indexed 2025-07-10T21:45:45Z
_version_ 1837298033852678144

Ähnliche Einträge