Antinociceptive Effects of an Extract of Securigera securidaca and their Mechanisms in Mice
We examined the effects of an aqueous extract from seeds of Securigera securidaca L. (S. s.), a plant used in folk medicine, on experimentally induced pain in balb-c mice. The tailflick test (somatic pain evoked by thermonociceptive stimulation) and writhing test (visceral pain after i.p. injecti...
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| Datum: | 2013 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут фізіології ім. О.О. Богомольця НАН України
2013
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| Schriftenreihe: | Нейрофизиология |
| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/148025 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Antinociceptive Effects of an Extract of Securigera securidaca and their Mechanisms in Mice / S. Shahidi, P. Pahlevani // Нейрофизиология. — 2013. — Т. 45, № 1. — С. 39-43. — Бібліогр.: 24 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | We examined the effects of an aqueous extract from seeds of Securigera securidaca L.
(S. s.), a plant used in folk medicine, on experimentally induced pain in balb-c mice. The tailflick
test (somatic pain evoked by thermonociceptive stimulation) and writhing test (visceral
pain after i.p. injections of acetic acid) were used. Three doses of the extract (85, 170, 340 mg
of dry substance per 1 kg body mass) were i.p. injected before the tests. Significant
antinociception effects were observed in both tests; a dose of 170 mg/kg appeared to be
optimum. Antinociceptive effects of the S. s. extract were comparable with those of 1 mg/kg
morphine. Naloxone, metoclopramide, ondancetron, and scopolamine (antagonists of
opioid, dopamine, serotonin, and cholinergic receptors, respectively) completely eliminated
antinociceptive effects of the S. s. extract in the tail-flick test; the effects of these antagonists
were not so clear in the writhing test. The mechanisms of analgesic actions of the S. s. extract
are discussed; the respective effects are probably related (at least partly) to the presence of
flavonoids in this extract. Further investigations are necessary for adequate interpretation of
the above mechanisms. |
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