Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms
In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate and tail flick...
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| Datum: | 2013 |
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Інститут фізіології ім. О.О. Богомольця НАН України
2013
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| Schriftenreihe: | Нейрофизиология |
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| Zitieren: | Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms / G.F. Ibironke, K.S. Rasak // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 380-384. — Бібліогр.: 19 назв. — англ. |
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irk-123456789-1481272019-02-18T01:24:17Z Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms Ibironke, G.F. Rasak, K.S. In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate and tail flick tests were observed.At the same time, times of licking the paw within the early and late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became significantly(P<0.05)smaller.Thus,forcedswimming-inducedstressresultsinthedevelopment of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg) and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (P > 0.05) the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acidinduced (writhing) tests. Thus, the histaminergic system is not significantly involved in the mechanisms of forced swimming-induced hypoalgesia. В експериментах на мишах ми вивчали вплив сеансів примусового плавання тривалістю 3 хв на показники, що характеризують стан ноцицептивної системи. Через 30 хв після епізодів примусового плавання ми спостерігали істотно (P < 0.05) коротші латентні періоди моторних реакцій у тестах “гарячої пластинки” та “відсмикування хвоста”. Водночас тривалість облизування лапи в межах ранньої та пізньої фаз формалінового тесту та кількість викликаних болем корчів у тесті з внутрішньоочеревинними ін’єкціями оцтової кислоти ставали істотно (P < 0.05) меншими. Отже, викликаний примусовим плаванням стрес призводить до розвитку стану гіпоалгезії щодо термоіндукованого болю, а також хемоіндукованого соматичного (формаліновий тест) та вісцерального (тест з використанням оцтової кислоти) болю. Блокатори гістамінових H1 (циметидін, 10 мг/кг) та H2 (хлорфенірамін, 15 мг/кг) рецепторів не впливали істотно (P > 0.05) на інтенсивність гіпоалгезії, викликаної примусовим плаванням, у тесті „відсмикування хвоста” та ацетатному тесті. Таким чином, гістамінергічна система не є залученою істотно в механізми індукованої примусовим плаванням гіпоалгезії. 2013 Article Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms / G.F. Ibironke, K.S. Rasak // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 380-384. — Бібліогр.: 19 назв. — англ. 0028-2561 http://dspace.nbuv.gov.ua/handle/123456789/148127 612.821.4 en Нейрофизиология Інститут фізіології ім. О.О. Богомольця НАН України |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| language |
English |
| description |
In experiments on mice, we examined the effects of 3-min-long forced swimming sessions
on indices characterizing the state of the nociceptive system. Thirty minutes after the forced
swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate
and tail flick tests were observed.At the same time, times of licking the paw within the early and
late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became
significantly(P<0.05)smaller.Thus,forcedswimming-inducedstressresultsinthedevelopment
of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin
test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg)
and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (P > 0.05)
the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acidinduced (writhing) tests. Thus, the histaminergic system is not significantly involved in the
mechanisms of forced swimming-induced hypoalgesia. |
| format |
Article |
| author |
Ibironke, G.F. Rasak, K.S. |
| spellingShingle |
Ibironke, G.F. Rasak, K.S. Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms Нейрофизиология |
| author_facet |
Ibironke, G.F. Rasak, K.S. |
| author_sort |
Ibironke, G.F. |
| title |
Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms |
| title_short |
Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms |
| title_full |
Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms |
| title_fullStr |
Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms |
| title_full_unstemmed |
Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms |
| title_sort |
forced swimming stress-related hypoalgesia: nondependence on the histaminergic mechanisms |
| publisher |
Інститут фізіології ім. О.О. Богомольця НАН України |
| publishDate |
2013 |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/148127 |
| citation_txt |
Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms / G.F. Ibironke, K.S. Rasak // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 380-384. — Бібліогр.: 19 назв. — англ. |
| series |
Нейрофизиология |
| work_keys_str_mv |
AT ibironkegf forcedswimmingstressrelatedhypoalgesianondependenceonthehistaminergicmechanisms AT rasakks forcedswimmingstressrelatedhypoalgesianondependenceonthehistaminergicmechanisms |
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2025-07-12T18:24:03Z |
| last_indexed |
2025-07-12T18:24:03Z |
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1837466538576183296 |