Effects of the Extract of Calophyllum Inophyllum on Behavioral Indices in Rodents
We examined modifications of behavioral indices evoked in rodents by introduction of an alcohol extract from leafs of Calophyllum inophyllum (С.i.) under conditions of four neurobehavioral tests. Intraperitoneal injections of 50, 100, or 200 mg/kg of the concentrated extract were used; the effect...
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| Date: | 2015 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2015
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| Series: | Нейрофизиология |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/148140 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Effects of the Extract of Calophyllum Inophyllum on Behavioral Indices in Rodents / G.F. Ibironke, O.G. Ugege // Нейрофизиология. — 2015. — Т. 47, № 1. — С. 49-54. — Бібліогр.: 16 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | We examined modifications of behavioral indices evoked in rodents by introduction of
an alcohol extract from leafs of Calophyllum inophyllum (С.i.) under conditions of four
neurobehavioral tests. Intraperitoneal injections of 50, 100, or 200 mg/kg of the concentrated
extract were used; the effects observed were compared with the action of 1 mg/kg diazepam.
In the hole-board test, injections of the C.i. extract significantly suppressed the manifestations
of research behavior (decreased the number of head dips into openings) in a dose-dependent
manner. In the light/dark box test, considerable increases of the time of stay of mice in the
dark compartment were observed after extract injections. In the open field test on mice,
injections of the C.i. extract resulted in noticeable, while statistically insignificant, decreases
in the general intensity of locomotion (number of crossed squares). In this test, the number
of manifestations of research behavior (rearings) decreased rather considerably; the number
of grooming episodes also became smaller, but suppression of this type of behavior was
weaker. Testing of rats in the elevated plus-maze showed that the numbers of entries of the
animals into open arms of the labyrinth significantly decreased at all doses of the extract,
and the duration of stay in these arms was also smaller. Thus, the extract from the C.i.
leafs containing significant amounts of biologically active compounds demonstrates rather
considerable sedative effects, but these effects are combined with some anxiogenic action.
The results obtained also show that anxiolythic/anxiogenic effects of a given test agent
observed in different behavioral tests (considered specific from this aspect) are not fully
identical and should be compared with reservations. |
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