Protective Effects of Regular Exercise Combined With Curcumin Supplementation Against Lead-Induced Cerebellar Oxidative Damage in an Animal Model
Lifestyle modifications, such as physical exercise and dietary supplements, were recommended as protective measures against some neurological disorders. We examined the effects of regular exercise combined with curcumin supplementation against lead-induced oxidative damage of the cerebellum in ma...
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| Date: | 2016 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2016
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| Series: | Нейрофизиология |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/148153 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Protective Effects of Regular Exercise Combined with Curcumin Supplementation Against Lead-Induced Cerebellar Oxidative Damage in an Animal Model / M. Habibian, S. J. Moosavi, P. Farzanegi // Нейрофизиология. — 2016. — Т. 48, № 1. — С. 20-25. — Бібліогр.: 36 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Lifestyle modifications, such as physical exercise and dietary supplements, were recommended
as protective measures against some neurological disorders. We examined the effects of
regular exercise combined with curcumin supplementation against lead-induced oxidative
damage of the cerebellum in male rats. Experimental animals (n = 50) were randomly divided
into five groups. Lead acetate (20 mg/kg) was i.p. administered to three groups (except sham
and control ones), while the sham group received ethyloleate (30 mg/kg) three times per
week. The curcumin and curcumin + exercise groups received curcumin (30 mg/kg) i.p. five
times per week for eight weeks. The exercise program consisted of progressive running on
a treadmill, speed from 15 to 22 m/min, 25 to 64 min per day, five times per week for eight
weeks. Two days after the last application, the rats were euthanized, and their cerebellum
was removed and homogenized to measure the levels of brain-derived neurotrophic factor
(BDNF) and thiobarbituric acid-reactive substances (TBARSs). Chronic administration
of lead significantly increased the cerebellar TBARS levels but did not alter considerably
the BDNF levels. Curcumin and curcumin + exercise treatments significantly lowered the
cerebellar TBARS levels; a significant increase in the BDNF level was observed in the
cerebellum of rats treated with combined intervention. Thus, regular exercise combined with
curcumin supplementation may exert a significant neuroprotective effect against lead-induced
cerebellar injury by attenuating oxidative stress and improving the brain state through an
increase in the BDNF amount. |
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