Analgesic and Anti-Inflammatory Effects of an Extract and Flavonoids from Artemisia Herba-Alba and Their Mechanisms of Action
Artemisia herba-alba (A. h.-a.) has wide use in traditional medicine for the relief of coughing, healing external wounds, and treatment of pain associated with gastrointestinal disturbances. We investigated in vivo antinociceptive and anti-inflammatory activities of an aqueous extract (aq. ex.) and...
Gespeichert in:
| Datum: | 2014 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут фізіології ім. О.О. Богомольця НАН України
2014
|
| Schriftenreihe: | Нейрофизиология |
| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/148280 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Analgesic and Anti-Inflammatory Effects of an Extract and Flavonoids from Artemisia Herba-Alba and Their Mechanisms of Action / E. Qnais, D. Raad, Y. Bseiso // Нейрофизиология. — 2014. — Т. 46, № 3. — С. 262-270. — Бібліогр.: 44 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Artemisia herba-alba (A. h.-a.) has wide use in traditional medicine for the relief of coughing, healing external wounds, and treatment of pain associated with gastrointestinal disturbances. We investigated in vivo antinociceptive and anti-inflammatory activities of an aqueous extract (aq. ex.) and two isolated compounds obtained from aerial parts of A. h.-a. The
analgesic effects of aq. ex. (10, 31.6, 100, 316, and 1000 mg/kg), astragalin, and eupatilin
(both, 0.316, 1, 3.16, 10, 31.6, and 100 mg/kg) were studied using the hot-plate test in mice
and formalin test in rats. The effects were compared with those of 5 mg/kg morphine. Dosedependent analgesic effects of aq. ex., astragalin, and eupatilin were clearly manifested in
both hot-plate assay and early and late phases of formalin-induced paw licking. These effects
were significantly but partly reduced by the opioid receptor antagonist naloxone (5 mg/kg).
The same range of doses of aq. ex., astragalin, and eupatilin caused dose-dependent suppression of carrageenan-induced paw edema in rats. Thus, we demonstrated that A. h.-a. possesses
noticeable antinociceptive and anti-inflammatory activities; our data support the reasons for
using this plant as a remedy for treatment of pain and inflammation. Antinociceptive and
anti-inflammatory actions of A. h.-a. are considerably related to the presence of astragalin
and eupatilin |
|---|