Modulatory Effects of the Glucocorticoid and Opioid Systems on Anxiety-Related Behavior in Young and Mature Rats
Considering that there is limited information on interaction between age and effects of the opioid system and glucocorticoids in determination of the level of anxiety, we examined the influences of 1 mg/kg dexamethasone and 20 mg/kg RU486 (as an agonist and an antagonist of glucocorticoid recepto...
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| Date: | 2016 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2016
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| Series: | Нейрофизиология |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/148314 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Modulatory Effects of the Glucocorticoid and Opioid Systems on Anxiety-Related Behavior in Young and Mature Rats / M. Kesmati, M. Rezai, M. Torabi // Нейрофизиология. — 2016. — Т. 48, № 3. — С. 205-211. — Бібліогр.: 31 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Considering that there is limited information on interaction between age and effects of the
opioid system and glucocorticoids in determination of the level of anxiety, we examined the
influences of 1 mg/kg dexamethasone and 20 mg/kg RU486 (as an agonist and an antagonist
of glucocorticoid receptors), and also of 5 mg/kg morphine and 20 mg/kg naloxone (as an
agonist and an antagonist of the opioid system) on the anxiety level in young and mature male
Wistar rats. The percentage of time in the open arms in the plus-maze test was evaluated as
an index of anxiety behavior, and the percentage of number of entries in the closed arms was
measured as an index of locomotor activity. The results showed that morphine (5 mg/kg)
and dexamethasone (1 mg/kg) exerted anxiolytic effects in both young and mature rats,
while only in young rats these agents reduced locomotor activity. RU486 could prevent the
anxiolytic effect of morphine, and the anxiolytic effect of dexamethasone was inhibited by
naloxone in young animals but this was not observed in mature rats. These results showed
that there is an interactive effect between glucocorticoids and the opioid system in mediation
of anxiety, and the respective events are age-dependent. |
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