Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles
The aim of present research was the investigation of antioxidant and antiexudative activities of the series of thiopyrano[2,3-d]thiazoles synthesized based on cinnamic acid amides. Methods. Organic synthesis; spectral methods; free radical scavenging assay (DPPH test); evaluation of antiexudative ac...
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| Datum: | 2015 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | English |
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Інститут молекулярної біології і генетики НАН України
2015
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| Schriftenreihe: | Вiopolymers and Cell |
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| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/152444 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles / A.V. Lozynskyi, D.V. Kaminskyy, Kh.B Romanchyshyn., N.G. Semenciv, V.V. Ogurtsov, I.O. Nektegayev, R.B. Lesyk // Вiopolymers and Cell. — 2015. — Т. 31, № 2. — С. 131-137. — Бібліогр.: 30 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | The aim of present research was the investigation of antioxidant and antiexudative activities of the series of thiopyrano[2,3-d]thiazoles synthesized based on cinnamic acid amides. Methods. Organic synthesis; spectral methods; free radical scavenging assay (DPPH test); evaluation of antiexudative activity (carrageenan oedema model in rats). Results. The evaluation of the free radicals scavenging activity and antiexudative activity of series of the 2-oxo-5-phenyl-7-aryl(hetaryl)-3,7-dihydro-2H-thiopyrano[2,3-d]thiazole-6-carboxylic acid amides was performed. Among the tested compounds, rel-(5R,6S,7S)-N-(4-methylphenyl)-7-(4-methylphenyl)-2-oxo-5-phenyl-3,5,6,7-tetrahydro-2H-thiopyrano[2,3-d]thiazole-6-carboxamide possessed the highest level of both activities. The experimental data most probably indicate a pronounced effect of methyl groups (phenyl fragments) on the realization of the anti-inflammatory and antioxidant effects and allow a suggestion about the antiradical mechanism of anti-inflammatory activity of the target compounds. Conclusions. The anti-inflammatory and free radicals scavenging activities of some tiopyrano[2,3-d]thiazoles have been established and the most active compounds were identified. Some findings of the structure-activity relationship were set up. |
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