MGMT expression: insights into its regulation. 1. Epigenetic factors
O⁶-methylguanine-DNA methyltransferase (MGMT) is the DNA repair enzyme responsible for removing of alkylation adducts from the O6-guanine in DNA. Despite MGMT prevents mutations and cell death, this enzyme can provide resistance of cancer cells to alkylating agents of chemotherapy. The high intra- a...
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| Date: | 2013 |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Інститут молекулярної біології і генетики НАН України
2013
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| Series: | Вiopolymers and Cell |
| Subjects: | |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/152497 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | MGMT expression: insights into its regulation. 1. Epigenetic factors / A.P. Iatsyshyna // Вiopolymers and Cell. — 2013. — Т. 29, №. 2. — С. 99-106. — Бібліогр.: 52 назв. — англ. |