Genetic and epigenetic alterations of human chromosome 3, investigated by NotI-microarrays in seven types of epithelial cancers
Aim. To identify common and specific genetic/epigenetic changes of human chromosome 3, using the data of NotI-microarrays in seven types of epithelial cancers. Methods. We used descriptive statistics for the comparative analysis of NotI-microarray data from seven types of epithelial cancers. Results...
Збережено в:
| Дата: | 2018 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
2018
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| Назва видання: | Інститут молекулярної біології і генетики НАН України |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/154277 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Genetic and epigenetic alterations of human chromosome 3, investigated by NotI-microarrays in seven types of epithelial cancers / G.V. Gerashchenko, V.V. Gordiyuk, V.I. Kashuba // Вiopolymers and Cell. — 2018. — Т. 34, № 4. — С. 303-312. — Бібліогр.: 37 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Aim. To identify common and specific genetic/epigenetic changes of human chromosome 3, using the data of NotI-microarrays in seven types of epithelial cancers. Methods. We used descriptive statistics for the comparative analysis of NotI-microarray data from seven types of epithelial cancers. Results. The analysis of the NotI-microarrays showed significant changes (deletion or methylation) in 74 genes/loci in seven different epithelial cancers, namely colorectal, ovarian, renal, lung, breast, cervical and prostate. Five genes from the 3p14-3p24 region (FOXP1, LRRC3B, NKiRAS1, RBSP3, ZIC4) were altered in all cancer types. For fifteen genes, deletion/methylation was found in a majority of tumors. For example, ITGA9, GORASP1, IQSEC1, CGGBP1, NBEAL2 and VHL are localized in the 3p12-3p26 region; PPP2R3A, FGF12, ALDH1L1, GATA2 and PLCL2 are localized the 3q13-3q28 region. Twenty-two genes out of 74 studied showed alterations specific for a single type of tumor. The largest number, 13 genes/loci was found in the prostate cancer. This suggests specific mechanisms of prostate cancer development. Conclusions. NotI-microarrays for human chromosome 3 allowed to identify several common genetic/epigenetic alterations and also tumor-specific changes in seven types of epithelial cancer. |
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