Study on association of the polymorphic variants of ACE (I/D), AT2R1 (A1166C), TNF-a (G308A), MTHFR (C677T) genes and their combinations with the risk of development of perinatal pathology and gestation reduction
Aim. To study the association of the polymorphic variants of ACE (I/D), AT2R1 (A1166C), TNF-á (G308A), MTHFR (C677T) genes and their combinations with the risk of perinatal pathology and gestation reduction. Methods. The polymorphic variants of genes were analyzed by PCR and RFLP in 235 newborns w...
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| Datum: | 2011 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | English |
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Інститут молекулярної біології і генетики НАН України
2011
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| Schriftenreihe: | Вiopolymers and Cell |
| Schlagworte: | |
| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/156340 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Study on association of the polymorphic variants of ACE (I/D), AT2R1 (A1166C), TNF-a (G308A), MTHFR (C677T) genes and their combinations with the risk of development of perinatal pathology and gestation reduction / N.G. Gorovenko, S.P. Kyryachenko, Z.I. Rossokha // Вiopolymers and Cell. — 2011. — Т. 27, № 3. — С. 206-213. — Бібліогр.: 14 назв. — англ., рос. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Aim. To study the association of the polymorphic variants of ACE (I/D), AT2R1 (A1166C), TNF-á (G308A),
MTHFR (C677T) genes and their combinations with the risk of perinatal pathology and gestation reduction.
Methods. The polymorphic variants of genes were analyzed by PCR and RFLP in 235 newborns with severe
perinatal pathology and 110 clinically healthy term newborns. Results. An increased risk of severe perinatal
pathology was associated with such genotypes: DD and ID (ACE), 1166AC, 1166CC (AT2R1), 677CT
(MTHFR), 308AA and 308AG (TNF-a), this risk for homozygotes is almost 2-fold higher than for heterozygotes.
Reduction of terms of gestation is associated with the genotype 677TT (MTHFR), and resistance to diseases in
the perinatal period – with the genotype II (ACE) and 1166AA (AT2R1), 677CC (MTHFR) and the 308GG (TNFa), particularly when com- bined. Conclusions. The identified associations evidence the role of polymorphic
variants of ACE, AT2R1, TNF-a, MTHFR genes in the development of severe perinatal pathology and can be
used for its early prediction with subsequent correction of treatment.
Keywords: perinatal pathology, polymorphism, ACE, AT2R1, TNF-a, MTHFR genes.. |
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