Region-specific nitric oxide production in cytosolic and mitochondrial compartments of the rat brain tissues following chronic stress-induced depression-like behavior
Aim. To study subcellular nitrergic response in the rat brain regions following chronic stress-induced depression-like behavior. Methods. An animal model of depression induced by chronic circadian stress (CCS) established in our laboratory was used. The L-arginine, L-citrulline and reactive nitrogen...
Gespeichert in:
| Datum: | 2011 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут молекулярної біології і генетики НАН України
2011
|
| Schriftenreihe: | Вiopolymers and Cell |
| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/156357 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Region-specific nitric oxide production in cytosolic and mitochondrial compartments of the rat brain tissues following chronic stress-induced depression-like behavior / N.S. Nazaryan, N.H. Movsesyan, N.Kh. Alchujyan, H.A. Movsesyan, A.G. Guevorkian, H.L. Hairapetyan, K.A. Barsegyan, G.A. Kevorkian // Вiopolymers and Cell. — 2011. — Т. 27, № 5. — С. 394-397. — Бібліогр.: 12 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Aim. To study subcellular nitrergic response in the rat brain regions following chronic stress-induced depression-like behavior. Methods. An animal model of depression induced by chronic circadian stress (CCS) established in our laboratory was used. The L-arginine, L-citrulline and reactive nitrogen species (RNS) levels were
determined spectrophotometrically. Results. Immediately after CCS and four dayslater, а depression-like behavior of rats was observed and accompanied by a substantial persistent elevation of the L-arginine, L-citrulline
and RNS levels with a simultaneous up-regulation of the inducible nitric oxide synthase (iNOS) in both cytosolic
and mitochondrial compartments of the rat prefrontal cortex, striatum, hippocampus, and hypothalamus, and a
down-regulation of their cytosolic constitutive NOS isoforms (cNOS), mitochondrial cNOS was not significantly
changed, with the exception for hypothalamus, in which the latter dropped. Conclusions. Compromised balance
of the L-arginine levels and NO synthesisin both mitochondria and cytosol in the limbic brain appearsto be implicated in the pathogenesis of depression and pathological anxiety.
Keywords: L-arginine, brain, chronic stress, depression-like behavior, mitochondria, nitric oxide synthase. |
|---|