Study on possible role of CYP1A1, GSTT1, GSTM1, GSTP1, NAT2 and ADRB2 genes polymorphisms in bronchial asthma development in children
Aim. To study the association of polymorphisms of the enzymes genes CYP1A1 (T6235C), first phase, and NAT2 (Ñ481Ò, G590A, G857A), GSTM1 («0»), GSTT1 («0») and GSTP1 (A313G), second phase of the detoxication system, as well as the ADRB2 (C79G) gene variants with the development of bronchial asthma...
Gespeichert in:
| Datum: | 2011 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут молекулярної біології і генетики НАН України
2011
|
| Schriftenreihe: | Вiopolymers and Cell |
| Schlagworte: | |
| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/156398 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Study on possible role of CYP1A1, GSTT1, GSTM1, GSTP1, NAT2 and ADRB2 genes polymorphisms in bronchial asthma development in children / P.F. Tatarskyy, N.G. Chumachenko, A.M. Kucherenko, R.V. Gulkovskyi, L.P. Arabskaya, O.A. Smirnova, S.I. Tolkach, Yu.G. Antipkin, L.A. Livshits // Вiopolymers and Cell. — 2011. — Т. 27, № 1. — С. 66-73. — Бібліогр.: 34 назв. — англ., укр. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Aim. To study the association of polymorphisms of the enzymes genes CYP1A1 (T6235C), first phase, and
NAT2 (Ñ481Ò, G590A, G857A), GSTM1 («0»), GSTT1 («0») and GSTP1 (A313G), second phase of the
detoxication system, as well as the ADRB2 (C79G) gene variants with the development of bronchial asthma
in children. Methods. Polymorphic variants were analyzed using PCR followed by RFLP analysis in 86
healthy individuals and in 114 patients with clinical diagnosis of bronchial asthma. Results. The frequency
of gene polymorphic variants of the enzymes of first and second phases of detoxification system as well as
the ADRB2 gene was established in the children with bronchial asthma and healthy individuals.
Conclusions. Ðolymorphic variants of the genes NAT2 (481Ò), GSTP1 (313G) and ADRB2 (79G) and their
combinations in geno- type were observed more frequently in the patients with bronchial asthma comparing
to the control group, which indicates their invol- vement in the pathogenesis of asthma in children
Keywords: bronchial asthma, detoxication system, 2-adrenoreceptor gene, polymorphism, combined
genotype. |
|---|