High selectivity of mutagenic action of synthetic polynucleotides
Solutions of high molecular weight syntetic poiyribo- and polydeoxyribonucleotides of known chemical structure injected into Drosophila melanogaster males caused a 6–17 fold increase of the overall frequency of the recessive lethals in the 2nd chromosome. Complementation analysis of the induced leth...
Збережено в:
| Дата: | 1999 |
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| Автор: | |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут молекулярної біології і генетики НАН України
1999
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| Назва видання: | Биополимеры и клетка |
| Теми: | |
| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/156535 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | High selectivity of mutagenic action of synthetic polynucleotides / Yu.N. Alexandrov // Биополимеры и клетка. — 1999. — Т. 15, № 4. — С. 257-261. — Бібліогр.: 19 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Solutions of high molecular weight syntetic poiyribo- and polydeoxyribonucleotides of known chemical structure injected into Drosophila melanogaster males caused a 6–17 fold increase of the overall frequency of the recessive lethals in the 2nd chromosome. Complementation analysis of the induced lethals showed an extremely high locus-specificity for some of these mutagens. Possible mechanisms of the mutagenic action of synthetic polynucleotides are discussed. |
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