Mother and Child Health
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| Datum: | 2012 |
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Інститут молекулярної біології і генетики НАН України
2012
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| Schriftenreihe: | Вiopolymers and Cell |
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irk-123456789-1568322019-06-20T01:26:35Z Mother and Child Health Abstracts of Research Networks’ Young Scientist Forum 2012 Article Mother and Child Health // Вiopolymers and Cell. — 2012. — Т. 28, № 2, доп. — С. 73-76. — англ. 0233-7657 http://dspace.nbuv.gov.ua/handle/123456789/156832 en Вiopolymers and Cell Інститут молекулярної біології і генетики НАН України |
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Abstracts of Research Networks’ Young Scientist Forum Abstracts of Research Networks’ Young Scientist Forum |
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Abstracts of Research Networks’ Young Scientist Forum Abstracts of Research Networks’ Young Scientist Forum Mother and Child Health Вiopolymers and Cell |
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Article |
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Mother and Child Health |
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Mother and Child Health |
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Mother and Child Health |
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Mother and Child Health |
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Mother and Child Health |
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mother and child health |
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Інститут молекулярної біології і генетики НАН України |
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2012 |
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Abstracts of Research Networks’ Young Scientist Forum |
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Mother and Child Health // Вiopolymers and Cell. — 2012. — Т. 28, № 2, доп. — С. 73-76. — англ. |
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Вiopolymers and Cell |
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2025-07-14T09:09:30Z |
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2025-07-14T09:09:30Z |
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1837612842125099008 |
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73
Mother and Child Health
74
Risk factors of deliveries in Slovak republic
1Lancz Kinga, 2Wsólová Ladislav, 1Trnovec Tomáš, 3Hinšt Jaroslav, 3Rusňák Igor
1Dept. of Environmental Medicine, Slovak Medical University, Bratislava, Slovakia
2Dept. of Biostatistics Analysis, Slovak Medical University, Bratislava, Slovakia
3Gyneacology and Obstetrics Clinic, University Hospital Bratislava, Slovakia
kinga.lancz@szu.sk
Aim: To identify risk factors associated with preterm birth (PTB) in Bratislava.
Methods: The clinical data of 7256 singleton deliveries by vaginal delivery or caesarean
section were retrospectively studied by the RECOOP HST Consortium Mother and Child
Health (MOCHEA) Research Network. From all deliveries 353 (4,9%) were preterm
births (24-36 gestational weeks) and 6903 (95,1%) full-term births (37-41 gestational
weeks). Pregnant women were admitted at the University Hospital in Bratislava from
January 2007 to December 2010. Information on medical history, developing problems
and special procedures performed during pregnancy was obtained from the medical
records.
Results: The mean age of the pregnant women was 29,67±4,98 years, gestational age
39,47±1,87 weeks, pre-pregnancy weight 63,77±12,19 kg, height 167,21±6,41cm and
BMI 22,79±4,16. From all pregnant women were 55,6% primipara, 68,5% married and
43,6% had secondary education with graduation and 7,9% smoked during pregnancy.
Several significant risk factors for PTB were identified by logistic regression analysis:
vaginal bleeding (OR=2,26; 95% CI=1,24-4,13), preeclampsia (OR=5,08; 95% CI=2,76-
9,37), cerclage (OR=7,86; 95% CI=2,49-24,86), medication for hypertension (OR=9,51;
95% CI=2,99-30,20), kidney diseases (OR=3,65; 95% CI=1,16-11,53), chorionic villi
sampling (OR=20,19; 95% CI=2,15-189,20) amniocentesis (OR=1,77; 95% CI=1,09-
2,89). Significant association was found in interaction of vaginal bleeding and use of iron
(OR=273,30; 95% CI=144,06-518,51). As protective factor of preterm birth were
observed: first trimester genetic screening (OR=0,48; 95% CI=0,24-0,93), first trimester
biomarkers (OR=0,17; 95% CI=0,09-0,31), medication for diabetes mellitus (OR=0,20;
95% CI=0,04-0,99) and use of iron (OR=0,21; 95% CI=0,12-0,35).
Conclusions: Interaction of vaginal bleeding in early pregnancy and use of iron is most
associated with an increased risk of PTB.
Keywords: full-term birth, PTB, risk factors.
75
Morbidity characteristics of late-preterm infants
Szalay Zs., Bekő B., Stalzer A., Berényi K.
Department of Neonatology, Obestrics and Gynecology, Public Health , Medical School, University of
Pécs
7624 Pécs, Édesanyák útja 17., Hungary
szalayeszterzsofia@gmail.com
Aim: The leading cause of infant mortality and morbidity is prematurity. In the first place
neonatal intensive care has paid attention to improve the quality of life of extremely low
birth weight neonates. However, we cannot forget the other subgroup of preterm
newborns, the late-preterm infants (defined as birth between completed 34-36 weeks
gestation). They give about 75% of preterm infants and the studies of the last few years
show that they are at higher risk of morbidity and mortality than term infants.
Methods: We examined the data of neonates who were born between January 1, 2009
and December 31, 2010 at the Department of Obstetrics and Gynecology, Medical
School, University of Pécs, Hungary. We compared the morbidity data of late-preterm
infants (n=414) to term infants who were born in the 40th gestational week (n=1235)
using t-test, Mann-Whitney-test, Kolmogorov-test, relative risk calculation with 95%
confidence interval. We analyzed the birth weight, length of hospitalisation, rate of
respiratory difficulties, oxygen therapy, infection, apnea, hypoglycemia and
hyperbilirubinemia.
Results: The mean birth weight of late-preterm infants was 2430g (SD: 520), which is
68.8% of the weight of term newborns. The mean length of hospitalisation of late-
preterm neonates was 2.8 times longer than that of term infants. Respiratory symptoms
developed 12.9 (RR: 12.93, CI: 8.41-19.87) times more often in late-preterm infants.
Oxygen therapy was applied in 24.2% of late-preterm infants and 45.7% had an infection
after birth. The incidence of apnea, hypoglycemia and hyperbilirubinemia was 13.4 (RR:
13.42, CI: 6.83-26.39), 6.7 (RR: 6.66, CI: 5.17-8.58) and 3.5 (RR: 3.47, CI: 2.41-5.00)
times higher in late-preterm infants than in term infants, respectively.
Conclusions: All analyzed clinical outcomes differed between late-preterm and term
infants significantly. Our results support the view that more attention should be paid to
this subgroup of preterm neonates.
Key words: late-preterm infants, neonatal adaptation
76
SNP’s in leptin (LEP) and leptin receptor (LEPR) genes are
associated with recurrent spontaneous abortion (RSA)
1,§Wagner J., 2,§Muller A., 1Škrlec I., 1Heffer M., 3Maver A., 4Zibar L., 3Peterlin B.
1 Department of Medical Biology, School of Medicine, J. J. Strossmayer University of Osijek, J.
Huttlera 4, 31000 Osijek, Croatia
2 Clinic for Gynecology and Obstetrics, University Hospital Centre Osijek, J. Huttlera 4, 31000 Osijek,
Croatia
3 Institute of Medical Genetics, University Medical Center Ljubljana, Šlajmerjeva 13, 1000 Ljubljana,
Slovenia
4 Clinic for Internal Medicine, University Hospital Centre Osijek, J. Huttlera 4, 31000 Osijek, Croatia
§Both authors contributed equally
jwagner@mefos.hr
Aim: Single nucleotide polymorphisms (SNP) in leptin (LEP) and leptin receptor (LEPR)
genes were compared between a group of female patients with more than three recurrent
spontaneous abortion (RSA) and women with two or more successful pregnancies (SP).
Methods: In a cohort study 145 women with SP and 178 women with RSA were tested.
Genotype of four SNP’s in LEP (rs7799039, rs2122627, rs11761556, rs10244329) and
four SNP’s in LEPR (rs1137101, rs7516341, rs1186403, rs12062820) were determined
using KASP SNP Genotyping system and ABI Prism 7000 SDS instrument. Statistical
comparison was done using Chi−square statistic. The haplotype frequencies and
haplotype−disease associations were estimated using haplo.stats package.
Results: The genotype frequencies did not deviate from HWE, except in the case of one
LEP and two LEPR SNPs. In the case of rs7799039 p value for RSA and all examinees
was 0.03. The recessive model (AG + GG/AA) revealed significant association between
2548A genotype and RSA (OR= 1.58). Also, two SNPs from intron region of LEPR
(rs7516341 and rs1186403) deviated from normal distribution. In dominant model
(CC+TC/TT) of the first SNP allele C decreases risk of RSA (p=0.034, OR=0.61). The
second SNP was significantly different for SP group (p=0.0078) where T allele is of
limited protective effect in the recessive model of inheritance (Chi-square p=0.082,
OR=0.51).
Conclusions: It is known that mother’s BMI during pregnancy influence maternal and
newborn health. LEP and LEPR are candidate genes for RSA and therefore their
influence on mother’s BMI during pregnancy and final outcome of pregnancy deserves
further investigation.
Keywords: recurrent spontaneous abortion, LEP, LEPR, SNP
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