Cedars’s Scientists in RECOOP HST
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| Datum: | 2012 |
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Інститут молекулярної біології і генетики НАН України
2012
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| Schriftenreihe: | Вiopolymers and Cell |
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irk-123456789-1568332019-06-20T01:26:29Z Cedars’s Scientists in RECOOP HST Abstracts of Cedars’s Scientists in RECOOP HST 2012 Article Cedars’s Scientists in RECOOP HST // Вiopolymers and Cell. — 2012. — Т. 28, № 2, доп. — С. 65-67. — англ. 0233-7657 http://dspace.nbuv.gov.ua/handle/123456789/156833 en Вiopolymers and Cell Інститут молекулярної біології і генетики НАН України |
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Abstracts of Cedars’s Scientists in RECOOP HST Abstracts of Cedars’s Scientists in RECOOP HST |
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Abstracts of Cedars’s Scientists in RECOOP HST Abstracts of Cedars’s Scientists in RECOOP HST Cedars’s Scientists in RECOOP HST Вiopolymers and Cell |
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Cedars’s Scientists in RECOOP HST |
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Cedars’s Scientists in RECOOP HST |
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Cedars’s Scientists in RECOOP HST |
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Інститут молекулярної біології і генетики НАН України |
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2012 |
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Cedars’s Scientists in RECOOP HST // Вiopolymers and Cell. — 2012. — Т. 28, № 2, доп. — С. 65-67. — англ. |
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Вiopolymers and Cell |
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65
Cedars’s Scientists in RECOOP HST
66
Parental perceptions of risks and benefits associated with a NICU
genetic biorepository
Simmons Charles F. Jr., Kotton Ryan, Khoury Nasif, Sullivan Shannon
Department of Pediatrics, Division of Neonatology, Maxine Dunitz Children’s Health Center Cedars-
Sinai Medical Center,
8700 Beverly Blvd., NT 4226, Los Angeles, CA 90048
charles.simmons@cshs.org
Aim: Due to widespread availability of archived neonatal screening samples, some
investigators propose genome-wide association study designs that utilize de-identified
DNA samples. The objective of this study was to determine parental perceptions of
potential risks and benefits associated with future genetic biorepository studies that
would utilize de-identified, archived DNA samples from NICU subjects of varying
ethnicity and gestational ages.
Methods: A 12 question, IRB approved survey was distributed to the parents of graduate
NICU patients. Of 283 surveys distributed, 109 surveys were completed; 107 after direct
personal encounter and 2 via mail. After eliciting informed consent, direct personal
contact occurred during a scheduled NICU follow up visit.
Results: 95% of directly contacted parents completed the survey, whereas only 1% of
surveys distributed via mail were completed (p<0.001). Of the completed surveys, 89%
of the parents were comfortable with the use of their child’s previously drawn, discarded
samples for future genetic research. 83% reported that they would likely consent to their
child’s participation in a future genetic biorepository. Conversely, the point estimate of
22% of parents (95% confidence interval 14.7-31.0) would either decline to archive
samples or participate in a future genetic biorepository study. Among the 83% of parents
likely to consent, the following reasons were listed: perceived potential benefit to their
own child (19.5%), to other children (37%), or to science (38%). Among the 17% of
parents unlikely to participate, the following reasons were listed: perceived potential
harm to their child (26%), potential discrimination (15%), potential privacy issues (15%)
and fear of potential new information or outcomes (10%). Fischer exact test did not
reveal any statistically significant differences between parental responses stratified by
self-identified ethnicity or gestational age at birth.
Conclusion: Although most NICU parents will consent to a NICU genetic biorepository
study, significant minorities perceive significant risks and would decline storage of their
child’s de-identified DNA for future genetic research. The fraction of parents who
decline is comparable across a range of self-identified ethnicity and gestational ages. In
order to protect all potential research subjects, prospective informed consent is a
requirement for ethical study design.
67
Bioavailability of vitamin D in obesity: an overview
1,2,3Arora Chander P. , 1Chatta Payush and 1,2Hobel Calvin J.
1 Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center,
Los Angeles CA, USA;
2 David Geffen School of Medicine, University of California Los Angeles,
Los Angeles, CA, USA;
3 International Research and Innovation Management, Cedars-Sinai Medical Center,
Los Angeles, CA, USA;
4 University of California Los Angeles,
Los Angeles, CA, USA
arora@cshs.org
Background: Obesity has been linked to many conditions including inflammation,
fatigue, muscle and bone aches, pressure sores, and high blood pressure. Vitamin D, a
steroid hormone, and leptin, a peptide hormone, are two essential factors that help target
obesity in the general population. Although the association between vitamin D and
obesity has been made clear through calcium regulation, the link between vitamin D and
leptin still seems to be unclear.
Objective: To assess the link between low levels of vitamin D, leptin and obesity.
Results: Vitamin D has recently been linked to obesity through an inverse relationship.
The content of the vitamin D3 precursor 7-dehydrocholesterol in the skin of obese and
non-obese subjects has not been reported to differ significantly. There appears to be a
spike in leptin levels with decreased vitamin D levels in obesity.
Conclusion: Different aspects associated with vitamin D deficiency in obese individuals
have been explored. Vitamin D insufficiency is associated with obesity due to the
decreased bioavailability of vitamin D3, instead it is deposited in adipose tissue. In vitro
studies indicate that obesity does not affect the cutaneous production of vitamin D.
Key words: Vitamin D, Obesity, Leptin
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