International conference “Tumor and host: novel aspects of old problem”
The International Conference “Tumor and Host: Novel Aspects of Old Problem” dedicated to the 50th anniversary of RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (IEPOR) of National Academy of Sciences of Ukraine (NASU) was held during September 21–24, 2010 in Kiev, Ukraine...
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| Дата: | 2011 |
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| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
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| Назва видання: | Experimental Oncology |
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| Онлайн доступ: | http://dspace.nbuv.gov.ua/handle/123456789/32321 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | International conference “Tumor and host: novel aspects of old problem” // Experimental Oncology. — 2011. — Т. 33, № 1. — С. 57–59. — англ. |
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irk-123456789-323212012-04-17T12:26:17Z International conference “Tumor and host: novel aspects of old problem” Meeting report The International Conference “Tumor and Host: Novel Aspects of Old Problem” dedicated to the 50th anniversary of RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (IEPOR) of National Academy of Sciences of Ukraine (NASU) was held during September 21–24, 2010 in Kiev, Ukraine. It was organized by IEPOR, and passed under patronage of the President of Ukraine Viktor Yanukovich. 2011 Article International conference “Tumor and host: novel aspects of old problem” // Experimental Oncology. — 2011. — Т. 33, № 1. — С. 57–59. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/32321 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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English |
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Meeting report Meeting report |
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Meeting report Meeting report International conference “Tumor and host: novel aspects of old problem” Experimental Oncology |
| description |
The International Conference “Tumor and Host: Novel Aspects of Old Problem” dedicated to the 50th anniversary of RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (IEPOR) of National Academy of Sciences of Ukraine (NASU) was held during September 21–24, 2010 in Kiev, Ukraine. It was organized by IEPOR, and passed under patronage of the President of Ukraine Viktor Yanukovich. |
| format |
Article |
| title |
International conference “Tumor and host: novel aspects of old problem” |
| title_short |
International conference “Tumor and host: novel aspects of old problem” |
| title_full |
International conference “Tumor and host: novel aspects of old problem” |
| title_fullStr |
International conference “Tumor and host: novel aspects of old problem” |
| title_full_unstemmed |
International conference “Tumor and host: novel aspects of old problem” |
| title_sort |
international conference “tumor and host: novel aspects of old problem” |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| publishDate |
2011 |
| topic_facet |
Meeting report |
| url |
http://dspace.nbuv.gov.ua/handle/123456789/32321 |
| citation_txt |
International conference “Tumor and host: novel aspects of old problem” // Experimental Oncology. — 2011. — Т. 33, № 1. — С. 57–59. — англ. |
| series |
Experimental Oncology |
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2025-07-03T12:50:10Z |
| last_indexed |
2025-07-03T12:50:10Z |
| _version_ |
1836630158862188544 |
| fulltext |
57 Experimental Oncology 33, 57–59, 2011 (March)
INTERNATIONAL CONFERENCE
“TUMOR AND HOST: NOVEL ASPECTS OF OLD PROBLEM”
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine,
Kyiv 03022, Ukraine
The International Conference “Tumor and Host:
Novel Aspects of Old Problem” dedicated to the 50th
anniversary of RE Kavetsky Institute of Experimental
Pathology, Oncology and Radiobiology (IEPOR) of Na
tional Academy of Sciences of Ukraine (NASU) was
held during September 21–24, 2010 in Kiev, Ukraine.
It was organized by IEPOR, and passed under patron
age of the President of Ukraine Viktor Yanukovich.
The Scientific Program covered the most important
topics of cancer research and was divided into five
Sessions:
1. “Tumor Biology and Immunology” that focused
on the basic aspects of tumor biology and immunology
in a single issue framework. Topics included mecha
nisms that determined metastasis and homing of tumor
cells, tumor angiogenesis and lymphangiogenesis, the
biology and molecular biology of cancer stem cells, im
munological aspects of tumor – host interaction.
2. “Metabolic and Stromal Microenvironment
of Tumor Cells” that focused on the tumor micro
environment as a key factor in tumor development
and progression. Topics included hypoxia signaling,
angiogenesis and aerobic glycolysis in human tumors
as a basis for diagnostics and anticancer strategies.
Key questions which were discussed: 1) Inflammation
and cancer: what is common and what is different?
2) Tumor hypoxia impact on tumor – host interaction:
a main regulator of malignant process outcome?
3. “Tumor markers: Signaling, Diagnosis and Prog
nosis” that covered fundamental and practical aspects
of tumor markers: identification of novel tumor markers,
peculiarity of signal transduction pathways in tumor
cells, application of tumor markers and cell differentia
tion antigens for cancer diagnosis and prognosis.
4. “Mechanism of Carcinogenesis and Cancer
Prevention” that focused on underlying mechanisms
of tumorigenesis and cancer prevention. Special em
phases were given: a) addressing the role of genetic and
epigenetic alterations and their interactions in cancer
development; and b) novel approaches for development
of sensitive and reliable biomarkers for early detection
and prevention of cancer, including nutrition.
5. “Cancer Therapy: New Technologies, Biothe
rapy, Individualization” that covered the clinical and
experimental investigations of cancer therapeutics
mediated through tumor – host interactions (bio
therapy, vascular disruptive therapy, etc.), validation
of new targets for cancer therapy and new strategies
for delivering therapy to tumors.
The Conference was officially opened by Presi
dent of the National Academy of Sciences of Ukraine
academician Boris E. Paton. The scientific part of the
meeting was started by academician Vasyl F. Chekhun
(IEPOR NASU, Kyiv, Ukraine) with lecture “The Concept
Tumor and Host in the PostGenomic Era” followed
by lecture “The Cancer Epigenome and Epigenetic
“Therapy” of Peter A. Jones (University of Southern
California/Norris Comprehensive Cancer Center, Los
Angeles, CA, USA).
Prof. P. Vaupel (Technical University of Munich,
Germany) presented the plenary lecture “Metabolic
microenvironment of tumor cells: a key factor in ma
lignant progression” and accented attention on the
impact of relevant pathophysiological factors, such
as chronic and fluctuating tissue hypoxia or anoxia,
acidosis, nutrient deprivation, energy depletion,
elevated vascular permeability and high interstitial fluid
pressure on tumor growth and malignant progression.
Prof. H. Friess (Technical University of Munich,
Germany) in the plenary lecture “Surgical procedure
as an inducer of tumor angiogenesis” discussed the
problem of surgical resection in the light of well known
fact that the healing process following surgery neces
sitates extensive angiogenesis, which can be a clinical
challenge due to its tumorpromoting effect. It was
suggested that initiation of antiangiogenesis thera
pies may be used for the early postoperative period
before the start of conventional chemotherapy.
Prof. G. Klein (Karolinska Institutet, Stockholm,
Sweden) presented a plenary lecture “Intercellular
surveillance against cancer” and decided to look for
variation in cancer resistance in humans, focusing
on one particular mechanism of resistance, namely
microenvironmental control (also called intercellular
surveillance). It was established that high throughput
system allows the quantitative analysis of the inhibitory
effect of fibroblasts on the population level and the
exploration of differences depending on the source
of the normal cells.
Prof. E. Klein (Karolinska Institutet, Stockholm, Swe
den) presented a plenary lecture “EBV causes mono
nucleosis, a common disease, but it was discovered
in a rare lymphoma”. It was discussed in the accordance
of recent studies that EBVencoded proteins can inhibit
myc induced apoptosis. Author has shown that the SAP
protein expressed in lymphocytes has a proapoptotic
function and assumed that the constitutively activated
myc can induce proliferation in such B lymphocytes
that lack SAP, while the myc translocation can induce
Exp Oncol 2011
33, 1, 57–59
MEETING REPORT
58 Experimental Oncology 33, 57–59, 2011 (March)
proliferation in EBV carrying cells even if they express
SAP because EBNA1 inhibits apoptosis.
Prof. M. Horsman (Aarhus University, Denmark)
concentrated on the tumor vasculature and vascular
targeting therapy and discussed significance two
forms of vascular targeting agents (VTAs): those
that inhibit the angiogenesis process (angiogenesis
inhibitors; AIs) and those that damage the already es
tablished vessels (vascular disrupting agents; VDAs).
Prof. J. Kleeff (Technical University of Munich, Ger
many) focused on the role of tumor microenvironment
in pancreatic cancer development and progression
and suggested to target the activated stroma in order
to uncouple epithelialstromal interactions to interrupt
multiple aberrant autocrine and paracrine pathways
that promote pancreatic cancer cell growth, invasion,
metastasis, and angiogenesis.
Prof. S. Osinsky (IEPOR NASU, Kyiv, Ukraine)
discussed the tumor cell microenvironment as a ma
chinery for tumorhost interaction and presented
recent data allowing to suggest that metabolic micro
environment of tumor cells (hypoxia, low extracellular
pH, low perfusion and high interstitial fluid pressure)
is a key factor determining the character and direction
of tumorhost interactions.
Prof. A. Sica (Fondazione Humanitas per la Ricerca,
Milan, Italy) discussed the role of tumorassociated
macrophages (TAM) in cancerrelated inflammation
and suggested that the development of effective
strategies to tip the balance by blocking cancer pro
moting inflammation and/or activating protective in
nate immunity may require definition of actors at play
at different anatomical sites and in different tumors.
Prof. N. Berezhnaya (IEPOR NASU, Kyiv, Ukraine)
discussed the aspects of interaction between tumor
and immune system with special attention to the role
of tumor cell biology and analyzed the involvement
of cytokines, chemokines, lymphocytes, and tumor
cells in the phenomenon of elevated sensitivity to LAK
action that can be particularly mediated by decreased
Ecadherin expression and increased CD40 expression.
Prof. M. Molls (Technical University Munich,
Germany) presented data about imaging of tumor
physiology through new methods of tumor visualization
and accented that the number of questions are kept
to be answered: How to assess 3Dimages of hypo
xia? How to account for changes of hypoxia over time?
How to assess the blood flow? What is a correlation
between imaging and histopathology?
Dr. N. Volodko (D Galytsky National Medical Uni
versity, Lviv, Ukraine) presented the data about the
relationship between microvessels density, degree
of macrophage infiltration, expression of TNF and TGFβ
in human ovarian cancer and its chemosensitivity.
Dr. A. Kovelskaya (IEPOR NASU, Kyiv, Ukraine) pre
sented data about hypoxia and tumorassociated mac
rophages (TAM) in human gastric cancer (GC) and their
impact on malignant progression concluding that the
severe tumor hypoxia and high TAMs are the para meters
that are associated with tumor aggressiveness, and can
be characterized as strong worse prognostic factors for
GC independently from the type of tumor treatment.
Dr. B. Gerashchenko (IEPOR NASU, Kyiv, Ukraine)
presented data on the hyperthermia effect of inter
action of proteins of the Mre11 complex (composed
of Mre11, Rad50 and Nbs1) that is involved in DSB
repair. Dr. N. Florovskaya (Murmansk Oncological Hos
pital, Russia) presented results of thermochemotherapy
of colorectal cancer patients with liver metastases
that improved the clinical outcome. Dr. I. Ganusevich
(IEPOR NASU, Kyiv, Ukraine) presented data about
MMP2 and 9 activities in tumor tissue and bone mar
row in the connection with disseminated tumor cells
as a prognostic factor for human gastric cancer outcome.
Session 3 “Tumor Markers: signaling, diagnosis
and prognosis” integrated conceptual reviews and
scientific reports covering different levels of biomedi
cal research: fundamental, translational research and
applied studies. In the plenary lecture Prof. Ivan Gout
(University College, London, UK) presented thorough
overview of mTOR (mammalian target of rapamycin)
signaling pathway in control of cell metabolism,
growth and proliferation and also its role in oncogenic
transformation. Tumorassociated changes in tran
sctiptome (Prof. V.M. Kavsan, Institute of Molecular
Biology and Genetics of NASU, Kyiv, Ukraine), pro
teome (Dr. P.V. Belousov, Chair of Immunology, Fac
ulty of Biology, Moscow State University, Moscow, Rus
sia) and deregulation of transcription factors in tumor
progression (Dr. N.L. Lazarevich, N.N. Blokhin Russian
Cancer Research Center, Moscow, Russia) formed
the block of lectures on molecular biology of tumors.
The role of signal transduction pathways in regula
tion of tumor cell biology was covered in lectures
on receptormediated signaling in Hodgkin lymphoma
cells (Drs. S.P. Sidorenko and M. Yurchenko, IEPOR
NASU, Kyiv, Ukraine) and the role of adaptor proteins
in cancerogenesis (Prof. L.B. Drobot, Palladin Institute
of Biochemistry of NASU, Kyiv, Ukraine). Presenta
tions of Dr. V.O. Nadgornaya and Prof. D.F. Gluzman
(IEPOR NASU, Kyiv, NASU) and also Dr. I.N. Kravchuk
(Institute of Molecular Biology and Genetics of NASU,
Kyiv, Ukraine) were devoted to leukemia markers,
while Dr. N.T. Pande (Division of Gynecological Onco
logy, Oregon Heath and Science university, USA) and
Prof. V.V. Filonenko (Institute of Molecular Biology
and Genetics of NASU, Kyiv, Ukraine) focused on new
markers of ovarian cancer. It should be noted that
oral and poster reports on translational and applied
stu dies included evaluation of tumor cell molecular
profile for prognosis and treatment individualization
(Dr. N.Yu. Lukianova, IEPOR NASU, Kyiv, Ukraine),
studies of mutant epidermal growth factor receptor and
MDM2 expression in ependymomas (Dr. E.S. Galanta,
Romodanov Institute of Neurosurgery, NAMSU, Kyiv,
Ukraine) and methylation status in colorectal tumors
(Dr. Gordiyuk, Institute of Molecular Biology and Ge
netics of NASU, Kyiv, Ukraine), and others.
The number of lectures and reports were presented
in the frame of Session 5. Prof. V.A. Shlyakhovenko
59 Experimental Oncology 33, 57–59, 2011 (March)
(IEPOR NASU, Kyiv, Ukraine) presented lecture on the in
vestigation of anticancer activity of glycopeptidic cancer
vaccine (GPV) and certain adjuvants against transplant
able metastasizing and nonmetastasizing tumors.
Invited lecture of Prof. N.F. Gamaleia (IEPOR
NASU, Kyiv, Ukraine) was devoted for the develop
ment of new approaches to improve photodynamic
therapy of malignant neoplasms, in particularly by the
modern bionanothechnology approaches using nano
composites, comprising both photosensitizing agent
and nanoparticles.
Dr. D.N. Kaluzhny (Institute of Molecular Biology
of RAS, Moscow, Russia) gave the insight into con
ventional and unusual DNA structures for anticancer
drug design.
Prof. V.G. Nikolaev (IEPOR NASU, Kyiv, Ukraine)
presented results of longterm investigations aimed
to use the methods of adsorptive therapy — hemo
sorption, enterosorption and application sorption
in oncologic practice with special attention on the new
generation of highly active sorbents as well as new
possibilities for the use of modern adsorptive tech
nologies in clinical oncology.
The invited lecture of Dr. G.I. Solyanik (IEPOR
NASU, Kyiv, Ukraine) was dedicated to multifactorial
nature of tumor drug resistance, in particular tumor
microenvironment (including tumor vascularization
and extracellular matrix) that plays an important role
in protecting cancer cells from initial drug exposure.
Prof. B.T. Bilynskyi (D. Galytsky National Medical
University, Lviv, Ukraine) in the invited lecture dis
cussed the influence of fundamental investigations
in biology and oncology on the clinical strategy and
tactics at the example of the breast cancer.
Dr. S. Souchelnytskyi (Karolinska institutet, Stock
holm, Sweden) presented data about role of proteome
signatures of immortalization, acquisition of high
proliferation potential in the formation of tumor and
metastases, especially correlation between compo
nents of the DRNet that provide a tool for diagnostics
and personalized treatment.
The conference was attended by 259 leading
experts of the experimental, clinical, medical, phar
maceutical oncology, as well as students and gradu
ate students of Universities and Research Institutes
of Ukraine, near and far abroad. The scientists from
14 countries were represented by 30 Academic and
24 Educational institutions. The media sector, in par
ticular television, radio, and newspapers has high
lighted the work of conference. Public and government
organizations including international ones have also
attended the conference.
Conference Organizing Committee
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