Poly(lactic acid) scaffolds modified by gelatin for the controlled release of tetrandrine in vitro
To mimic natural extracellular matrix architecture, tetrandrine-loaded poly(L-lactic acid) scaffolds modified by gelatin were prepared via phase separation, solvent replacement and freeze-drying. The purpose of this work was to combine the biological effects of tetrandrine and the advantages of poly...
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| Date: | 2017 |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
НТК «Інститут монокристалів» НАН України
2017
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| Series: | Functional Materials |
| Subjects: | |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Poly(lactic acid) scaffolds modified by gelatin for the controlled release of tetrandrine in vitro / Zhang Ye // Functional Materials. — 2017. — Т. 24, № 4. — С. 660-666. — Бібліогр.: 34 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | To mimic natural extracellular matrix architecture, tetrandrine-loaded poly(L-lactic acid) scaffolds modified by gelatin were prepared via phase separation, solvent replacement and freeze-drying. The purpose of this work was to combine the biological effects of tetrandrine and the advantages of poly(L-lactic acid) scaffolds which was modified by gelatin to enhancing the mass transfer features of controlled release systems. Tetrandrine contained in the scaffolds was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared (FT-IR) spectroscopy. Tetrandrine did not change the morphous, crystallinity and thermodynamics of the scaffolds which demonstrated by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray powder diffractometry (XRD). The results of this study showed a sustained release with 79.15% for 188 days in vitro. |
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