Effect of combined treatment with insulin and metformin on 5′AMPactivated protein kinase activity in lymphocytes of diabetic patients
The activity of 5′adenosine monophosphate-activated protein kinase (AMPK), controlling the energy balance of a cell, in blood cells at the combined treatment of patients with type 2 diabetes with metformin and insulin was determined by enzyme immunoassay. It has been shown that metformin increase...
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| Date: | 2018 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Видавничий дім "Академперіодика" НАН України
2018
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| Series: | Доповіді НАН України |
| Subjects: | |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Effect of combined treatment with insulin and metformin on 5’AMPactivated protein kinase activity in lymphocytes of diabetic patients / L.K. Sokolova, V.M. Pushkarev, Y.B. Belchina, V.V. Pushkarev, M.D. Tronko // Доповіді Національної академії наук України. — 2018. — № 5. — С. 100-104. — Бібліогр.: 11 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | The activity of 5′adenosine monophosphate-activated
protein kinase (AMPK), controlling the energy balance of
a cell, in blood cells at the combined treatment of patients with type 2 diabetes with metformin and insulin was
determined by enzyme immunoassay. It has been shown that metformin increases threefold
the AMPK activity in
lymphocytes of patients with type 2 diabetes, compared with patients before treatment. Insulin and its analog
reduced the activity of the protein kinase stimulated by metformin in the blood cells, acting as metformin antagonists.
The mechanisms of drug interaction and the consequences of their antagonism are discussed. |
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