Modern views on the structure and dynamics of biological membranes
Essential changes have been recently observed in views on the functioning, structural and dynamic properties of biological membranes. The previous results on hierarchical cluster-type structure of membranes and role of protein and lipid components are reconsidered. An established fact of dramatic di...
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| Дата: | 2012 |
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| Автор: | |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут молекулярної біології і генетики НАН України
2012
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| Назва видання: | Вiopolymers and Cell |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Modern views on the structure and dynamics of biological membranes / A.P. Demchenko // Вiopolymers and Cell. — 2012. — Т. 28, № 1. — С. 24-38. — Бібліогр.: 114 назв. — англ., укр. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Резюме: | Essential changes have been recently observed in views on the functioning, structural and dynamic properties of biological membranes. The previous results on hierarchical cluster-type structure of membranes and role of protein and lipid components are reconsidered. An established fact of dramatic difference in lipid composition between external and internal monolayers of plasma membranes is important for understanding membrane phenomena. In particular, there exist the differences between monolayers in surface charge and potential, ion binding, interaction with protein molecules, etc. A glycolipid component of outer monolayer and interaction of inner monolayer with cytoskeleton allow the membrane by expanding the asymmetry to attain its important functional properties. All that requires more critical approach to numerous data obtained with simplified biomembrane analogs – lipid and protein-lipid bilayer structures. In the attempts to describe and model the properties of cellular membranes there is a timely necessity to shift from two-dimensionality (which reduces the analysis to membrane plane only) to more realistic three-dimensional models. |
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