Фрагмент-орієнтований дизайн лікарських засобів
Fragment-based drug design (FBDD) is one of the modern techniques used for developing new drugs, and an alternative to the widely used high throughput screening. The main methodological approaches of FBDD, as well as the methods of optimization for the identified “fragments“ when transferring them t...
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| Datum: | 2017 |
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| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | Ukrainian |
| Veröffentlicht: |
National University of Pharmacy
2017
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| Schlagworte: | |
| Online Zugang: | https://ophcj.nuph.edu.ua/article/view/ophcj.17.913 |
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| Назва журналу: | Journal of Organic and Pharmaceutical Chemistry |
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Journal of Organic and Pharmaceutical Chemistry| Zusammenfassung: | Fragment-based drug design (FBDD) is one of the modern techniques used for developing new drugs, and an alternative to the widely used high throughput screening. The main methodological approaches of FBDD, as well as the methods of optimization for the identified “fragments“ when transferring them to the drug-like molecules have been described. The basic principles of the biophysical methods for analysis of the fragment – bio-target complexes and their application have been shown. Advantages and disadvantages of such methods as fluorescence-based thermal shift, NMR-spectroscopy, mass spectrometry, surface plasmon resonance are discussed. The most informative and efficient tool for the complex screening is X-ray crystallography. The main approaches to development of the pharmacologically active molecules based on the identified fragments, namely the methods of “fragment merging”, “fragment linking” and “fragment growing”, are given. The prospects and importance of the given method has been confirmed by the specific examples of drug candidates and the antitumor drug Vemurafenib approved and developed using FBDD. |
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