Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution
A new approach has been developed for synthesizing important compounds with potential biological activity − enantiomerically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids. The kinetic dynamic enzymatic resolution methodology was applied at key synthesis stages. A dual biocatalyt...
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| Datum: | 2025 |
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V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2025
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oai:ojs2.bioorganica.com.ua:article-972025-06-30T20:57:41Z Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution Kolodiazhna, Anastasiia O. Faiziiev, Oleh O. Prysiazhnuk, Dmytro V. biocatalysis chiral heterocyclic compounds chiral 3-heterylbutanoic acids 3-heteryl-2-methylpropanoic acids lipase enzymatic resolution optical activity A new approach has been developed for synthesizing important compounds with potential biological activity − enantiomerically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids. The kinetic dynamic enzymatic resolution methodology was applied at key synthesis stages. A dual biocatalytic purification method was employed to achieve a high degree of optical purity of the obtained products. The resulting amines are promising building blocks for the development and production of new pharmaceuticals and biologically active compounds V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025-06-30 Article Article https://bioorganica.com.ua/index.php/journal/article/view/97 Ukrainica Bioorganica Acta; Vol. 20 No. 1 (2025): Ukrainica Bioorganica Acta; 31-37 Ukrainica Bioorganica Acta; Том 20 № 1 (2025): Ukrainica Bioorganica Acta; 31-37 1814-9766 1814-9758 Copyright (c) 2025 Ukrainica Bioorganica Acta https://creativecommons.org/licenses/by/4.0/ |
| institution |
Ukrainica Bioorganica Acta |
| baseUrl_str |
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| datestamp_date |
2025-06-30T20:57:41Z |
| collection |
OJS |
| topic_facet |
biocatalysis chiral heterocyclic compounds chiral 3-heterylbutanoic acids 3-heteryl-2-methylpropanoic acids lipase enzymatic resolution optical activity |
| format |
Article |
| author |
Kolodiazhna, Anastasiia O. Faiziiev, Oleh O. Prysiazhnuk, Dmytro V. |
| spellingShingle |
Kolodiazhna, Anastasiia O. Faiziiev, Oleh O. Prysiazhnuk, Dmytro V. Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| author_facet |
Kolodiazhna, Anastasiia O. Faiziiev, Oleh O. Prysiazhnuk, Dmytro V. |
| author_sort |
Kolodiazhna, Anastasiia O. |
| title |
Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| title_short |
Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| title_full |
Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| title_fullStr |
Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| title_full_unstemmed |
Synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| title_sort |
synthesis of optically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids by biocatalytic resolution |
| description |
A new approach has been developed for synthesizing important compounds with potential biological activity − enantiomerically pure 3-heteroaryl-2-methylpropanoic and 3-heteroarylbutanoic acids. The kinetic dynamic enzymatic resolution methodology was applied at key synthesis stages. A dual biocatalytic purification method was employed to achieve a high degree of optical purity of the obtained products. The resulting amines are promising building blocks for the development and production of new pharmaceuticals and biologically active compounds |
| publisher |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine |
| publishDate |
2025 |
| url |
https://bioorganica.com.ua/index.php/journal/article/view/97 |
| work_keys_str_mv |
AT kolodiazhnaanastasiiao synthesisofopticallypure3heteroaryl2methylpropanoicand3heteroarylbutanoicacidsbybiocatalyticresolution AT faiziievoleho synthesisofopticallypure3heteroaryl2methylpropanoicand3heteroarylbutanoicacidsbybiocatalyticresolution AT prysiazhnukdmytrov synthesisofopticallypure3heteroaryl2methylpropanoicand3heteroarylbutanoicacidsbybiocatalyticresolution |
| first_indexed |
2025-07-17T12:20:09Z |
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2025-07-17T12:20:09Z |
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