Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias
Summary. Aim: To determine ways of formation of abnormal karyotypes in two clinical cases of secondary acute leukemias of myeloid and lymphoid lineages. Material and Methods: Bone marrow cells of one patient with therapy-related acute monoblastic/monocytic leukemia and one patient with therapy-relat...
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| Дата: | 2023 |
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| Мова: | English |
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PH Akademperiodyka
2023
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| Назва журналу: | Experimental Oncology |
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Experimental Oncology| id |
oai:ojs2.ex.aqua-time.com.ua:article-190 |
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Experimental Oncology |
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2023-10-11T16:43:03Z |
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| language |
English |
| topic |
chromosomal abnormalities chromothripsis complex karyotype prognostic significance therapy-related leukemia |
| spellingShingle |
chromosomal abnormalities chromothripsis complex karyotype prognostic significance therapy-related leukemia Andreieva, S.V. Kyselova, O.A. Serbin, I.M. Alkhimova, O.G. Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| topic_facet |
chromosomal abnormalities chromothripsis complex karyotype prognostic significance therapy-related leukemia chromosomal abnormalities chromothripsis complex karyotype prognostic significance therapy-related leukemia |
| format |
Article |
| author |
Andreieva, S.V. Kyselova, O.A. Serbin, I.M. Alkhimova, O.G. |
| author_facet |
Andreieva, S.V. Kyselova, O.A. Serbin, I.M. Alkhimova, O.G. |
| author_sort |
Andreieva, S.V. |
| title |
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| title_short |
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| title_full |
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| title_fullStr |
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| title_full_unstemmed |
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| title_sort |
peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| title_alt |
Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias |
| description |
Summary. Aim: To determine ways of formation of abnormal karyotypes in two clinical cases of secondary acute leukemias of myeloid and lymphoid lineages. Material and Methods: Bone marrow cells of one patient with therapy-related acute monoblastic/monocytic leukemia and one patient with therapy-related acute lymphoblastic leukemia were examined by cytogenetic GTG banding technique. Results: An unusually large number of quantitative and structural anomalies of chromosomes in therapy-related acute monoblastic/monocytic leukemia have been established, which have many features in common with chromothripsis, namely instability of clones that manifested itself through quantitative anomalies (trisomy, monosomy, marker chromosomes, including chromosome 5), structural — t(9;11), deletions of the long arm of chromosomes 8 and 14, derivatives of chromosomes 3 and 7, ring chromosomes. In case of secondary acute lymphoblastic leukemia, the anomalous clone with balanced translocation in all 20 metaphase plates 46,XX,t(1;15)(p21;q24) has been registered, which is not described in the literature. Therefore, the diagnostic and prognostic value of such anomaly is unknown. Conclusions: Rearrangement with the involvement of the locus 11q23 was recorded in the case of chemotherapy treatment without topoisomerase II inhibitors. The complex karyotype formed after chemotherapy and radiotherapy, which is a criterion for an unfavorable prognosis of the disease, is considered as the equivalent of chromothripsis. t(1;15) is considered as an abnormality that can be attributed to the group of favorable secondary acute lymphoblastic leukemia prognosis. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-7 |
| work_keys_str_mv |
AT andreievasv peculiaritiesofabnormalkaryotypesformationintherapyrelatedacuteleukemias AT kyselovaoa peculiaritiesofabnormalkaryotypesformationintherapyrelatedacuteleukemias AT serbinim peculiaritiesofabnormalkaryotypesformationintherapyrelatedacuteleukemias AT alkhimovaog peculiaritiesofabnormalkaryotypesformationintherapyrelatedacuteleukemias |
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2025-07-17T12:16:18Z |
| last_indexed |
2025-07-17T12:16:18Z |
| _version_ |
1837896385904508928 |
| spelling |
oai:ojs2.ex.aqua-time.com.ua:article-1902023-10-11T16:43:03Z Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias Peculiarities of abnormal karyotypes formation in therapy-related acute leukemias Andreieva, S.V. Kyselova, O.A. Serbin, I.M. Alkhimova, O.G. chromosomal abnormalities, chromothripsis, complex karyotype, prognostic significance, therapy-related leukemia chromosomal abnormalities, chromothripsis, complex karyotype, prognostic significance, therapy-related leukemia Summary. Aim: To determine ways of formation of abnormal karyotypes in two clinical cases of secondary acute leukemias of myeloid and lymphoid lineages. Material and Methods: Bone marrow cells of one patient with therapy-related acute monoblastic/monocytic leukemia and one patient with therapy-related acute lymphoblastic leukemia were examined by cytogenetic GTG banding technique. Results: An unusually large number of quantitative and structural anomalies of chromosomes in therapy-related acute monoblastic/monocytic leukemia have been established, which have many features in common with chromothripsis, namely instability of clones that manifested itself through quantitative anomalies (trisomy, monosomy, marker chromosomes, including chromosome 5), structural — t(9;11), deletions of the long arm of chromosomes 8 and 14, derivatives of chromosomes 3 and 7, ring chromosomes. In case of secondary acute lymphoblastic leukemia, the anomalous clone with balanced translocation in all 20 metaphase plates 46,XX,t(1;15)(p21;q24) has been registered, which is not described in the literature. Therefore, the diagnostic and prognostic value of such anomaly is unknown. Conclusions: Rearrangement with the involvement of the locus 11q23 was recorded in the case of chemotherapy treatment without topoisomerase II inhibitors. The complex karyotype formed after chemotherapy and radiotherapy, which is a criterion for an unfavorable prognosis of the disease, is considered as the equivalent of chromothripsis. t(1;15) is considered as an abnormality that can be attributed to the group of favorable secondary acute lymphoblastic leukemia prognosis. Summary. Aim: To determine ways of formation of abnormal karyotypes in two clinical cases of secondary acute leukemias of myeloid and lymphoid lineages. Material and Methods: Bone marrow cells of one patient with therapy-related acute monoblastic/monocytic leukemia and one patient with therapy-related acute lymphoblastic leukemia were examined by cytogenetic GTG banding technique. Results: An unusually large number of quantitative and structural anomalies of chromosomes in therapy-related acute monoblastic/monocytic leukemia have been established, which have many features in common with chromothripsis, namely instability of clones that manifested itself through quantitative anomalies (trisomy, monosomy, marker chromosomes, including chromosome 5), structural — t(9;11), deletions of the long arm of chromosomes 8 and 14, derivatives of chromosomes 3 and 7, ring chromosomes. In case of secondary acute lymphoblastic leukemia, the anomalous clone with balanced translocation in all 20 metaphase plates 46,XX,t(1;15)(p21;q24) has been registered, which is not described in the literature. Therefore, the diagnostic and prognostic value of such anomaly is unknown. Conclusions: Rearrangement with the involvement of the locus 11q23 was recorded in the case of chemotherapy treatment without topoisomerase II inhibitors. The complex karyotype formed after chemotherapy and radiotherapy, which is a criterion for an unfavorable prognosis of the disease, is considered as the equivalent of chromothripsis. t(1;15) is considered as an abnormality that can be attributed to the group of favorable secondary acute lymphoblastic leukemia prognosis. PH Akademperiodyka 2023-06-01 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-7 10.32471/exp-oncology.2312-8852.vol-42-no-2.14593 Experimental Oncology; Vol. 42 No. 2 (2020): Experimental Oncology; 126-129 Експериментальна онкологія; Том 42 № 2 (2020): Експериментальна онкологія; 126-129 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-2 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-7/2020-2-7 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |