Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
Summary. Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Meth...
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| Дата: | 2023 |
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| Формат: | Стаття |
| Мова: | English |
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PH Akademperiodyka
2023
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-1962023-10-11T16:43:03Z Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin Lamdan, H. Garcia-Lazaro, R.S. Lorenzo, N. Caligiuri, L.G. Alonso, D.F. Farina, H.G. anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols Summary. Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Summary. Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. PH Akademperiodyka 2023-06-01 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-13 10.32471/exp-oncology.2312-8852.vol-42-no-2.14766 Experimental Oncology; Vol. 42 No. 2 (2020): Experimental Oncology; 101-108 Експериментальна онкологія; Том 42 № 2 (2020): Експериментальна онкологія; 101-108 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-2 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-13/2020-2-13 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
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Experimental Oncology |
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| datestamp_date |
2023-10-11T16:43:03Z |
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OJS |
| language |
English |
| topic |
anthocyanins anti-proliferative blueberry extract cancer polyphenols |
| spellingShingle |
anthocyanins anti-proliferative blueberry extract cancer polyphenols Lamdan, H. Garcia-Lazaro, R.S. Lorenzo, N. Caligiuri, L.G. Alonso, D.F. Farina, H.G. Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| topic_facet |
anthocyanins anti-proliferative blueberry extract cancer polyphenols anthocyanins anti-proliferative blueberry extract cancer polyphenols |
| format |
Article |
| author |
Lamdan, H. Garcia-Lazaro, R.S. Lorenzo, N. Caligiuri, L.G. Alonso, D.F. Farina, H.G. |
| author_facet |
Lamdan, H. Garcia-Lazaro, R.S. Lorenzo, N. Caligiuri, L.G. Alonso, D.F. Farina, H.G. |
| author_sort |
Lamdan, H. |
| title |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| title_short |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| title_full |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| title_fullStr |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| title_full_unstemmed |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| title_sort |
anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| title_alt |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
| description |
Summary. Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-13 |
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