High expression of GLI1 is associated with better survival in advanced SCLC
Summary. Aim: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data corr...
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PH Akademperiodyka
2023
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oai:ojs2.ex.aqua-time.com.ua:article-2092023-10-11T16:42:32Z High expression of GLI1 is associated with better survival in advanced SCLC High expression of GLI1 is associated with better survival in advanced SCLC Kozirovskis, V. Zandberga, E. Magone, M. Purkalne, G. Linē, A. Vikmanis, U. GLI1, prognosis, small cell lung cancer, Sonic hedgehog pathway, survival GLI1, prognosis, small cell lung cancer, Sonic hedgehog pathway, survival Summary. Aim: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival. Materials and Methods: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor’s samples (stratified by median survival, independent samples t-test). Results: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor’s biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test). Conclusion: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study. Summary. Aim: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival. Materials and Methods: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor’s samples (stratified by median survival, independent samples t-test). Results: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor’s biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test). Conclusion: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study. PH Akademperiodyka 2023-06-01 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-13 10.32471/exp-oncology.2312-8852.vol-42-no-1.14266 Experimental Oncology; Vol. 42 No. 1 (2020): Experimental Oncology; 75-77 Експериментальна онкологія; Том 42 № 1 (2020): Експериментальна онкологія; 75-77 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-1 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-13/2020-1-13 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2023-10-11T16:42:32Z |
| collection |
OJS |
| language |
English |
| topic |
GLI1 prognosis small cell lung cancer Sonic hedgehog pathway survival |
| spellingShingle |
GLI1 prognosis small cell lung cancer Sonic hedgehog pathway survival Kozirovskis, V. Zandberga, E. Magone, M. Purkalne, G. Linē, A. Vikmanis, U. High expression of GLI1 is associated with better survival in advanced SCLC |
| topic_facet |
GLI1 prognosis small cell lung cancer Sonic hedgehog pathway survival GLI1 prognosis small cell lung cancer Sonic hedgehog pathway survival |
| format |
Article |
| author |
Kozirovskis, V. Zandberga, E. Magone, M. Purkalne, G. Linē, A. Vikmanis, U. |
| author_facet |
Kozirovskis, V. Zandberga, E. Magone, M. Purkalne, G. Linē, A. Vikmanis, U. |
| author_sort |
Kozirovskis, V. |
| title |
High expression of GLI1 is associated with better survival in advanced SCLC |
| title_short |
High expression of GLI1 is associated with better survival in advanced SCLC |
| title_full |
High expression of GLI1 is associated with better survival in advanced SCLC |
| title_fullStr |
High expression of GLI1 is associated with better survival in advanced SCLC |
| title_full_unstemmed |
High expression of GLI1 is associated with better survival in advanced SCLC |
| title_sort |
high expression of gli1 is associated with better survival in advanced sclc |
| title_alt |
High expression of GLI1 is associated with better survival in advanced SCLC |
| description |
Summary. Aim: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival. Materials and Methods: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor’s samples (stratified by median survival, independent samples t-test). Results: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor’s biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test). Conclusion: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-13 |
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2025-07-17T12:16:34Z |
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2025-07-17T12:16:34Z |
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