FUT3 expression in human breast cancer cells under hypoxia and serum deprivation
Summary. This study aimed to investigate the effects of hypoxia and serum deprivation on regulation of fucosyltransferase-3 (FUT3) expression in breast cancer cells. Materials and Methods: FUT3 expression was evaluated in T47D and MCF7 cells. Transcriptional and protein analysis was performed under...
Збережено в:
| Дата: | 2023 |
|---|---|
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
PH Akademperiodyka
2023
|
| Теми: | |
| Онлайн доступ: | https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-4 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Experimental Oncology |
Репозитарії
Experimental Oncology| id |
oai:ojs2.ex.aqua-time.com.ua:article-214 |
|---|---|
| record_format |
ojs |
| spelling |
oai:ojs2.ex.aqua-time.com.ua:article-2142023-10-11T16:42:06Z FUT3 expression in human breast cancer cells under hypoxia and serum deprivation FUT3 expression in human breast cancer cells under hypoxia and serum deprivation Albuquerque, A.P.B. Silva, A.L.V. Lima, C.A.D. Beltrão, E.I.C. breast cancer, FUT3, hypoxic microenvironment, serum deprivationv breast cancer, FUT3, hypoxic microenvironment, serum deprivation Summary. This study aimed to investigate the effects of hypoxia and serum deprivation on regulation of fucosyltransferase-3 (FUT3) expression in breast cancer cells. Materials and Methods: FUT3 expression was evaluated in T47D and MCF7 cells. Transcriptional and protein analysis was performed under hypoxia and serum deprivation conditions after 6 and 24 hours; and after 24 and 48 hours, respectively. Results: In T47D cells, experimental conditions induced a significant decrease in FUT3 expression at both, transcriptional and protein levels, while in MCF7 cells the same conditions induced a significant increase of FUT3 expression. Conclusions: Regulation of FUT3 expression under hypoxic and serum deprivation conditions may be involved in the acquisition of advantages related to apoptosis resistance and metastasis promotion, according to the intrinsic differences presented by T47D and MCF7 cells. Summary. This study aimed to investigate the effects of hypoxia and serum deprivation on regulation of fucosyltransferase-3 (FUT3) expression in breast cancer cells. Materials and Methods: FUT3 expression was evaluated in T47D and MCF7 cells. Transcriptional and protein analysis was performed under hypoxia and serum deprivation conditions after 6 and 24 hours; and after 24 and 48 hours, respectively. Results: In T47D cells, experimental conditions induced a significant decrease in FUT3 expression at both, transcriptional and protein levels, while in MCF7 cells the same conditions induced a significant increase of FUT3 expression. Conclusions: Regulation of FUT3 expression under hypoxic and serum deprivation conditions may be involved in the acquisition of advantages related to apoptosis resistance and metastasis promotion, according to the intrinsic differences presented by T47D and MCF7 cells. PH Akademperiodyka 2023-06-02 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-4 10.32471/exp-oncology.2312-8852.vol-41-no-4.13727 Experimental Oncology; Vol. 41 No. 4 (2019): Experimental Oncology; 318-322 Експериментальна онкологія; Том 41 № 4 (2019): Експериментальна онкологія; 318-322 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-4 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-4/2019-4-4 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2023-10-11T16:42:06Z |
| collection |
OJS |
| language |
English |
| topic |
breast cancer FUT3 hypoxic microenvironment serum deprivationv |
| spellingShingle |
breast cancer FUT3 hypoxic microenvironment serum deprivationv Albuquerque, A.P.B. Silva, A.L.V. Lima, C.A.D. Beltrão, E.I.C. FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| topic_facet |
breast cancer FUT3 hypoxic microenvironment serum deprivationv breast cancer FUT3 hypoxic microenvironment serum deprivation |
| format |
Article |
| author |
Albuquerque, A.P.B. Silva, A.L.V. Lima, C.A.D. Beltrão, E.I.C. |
| author_facet |
Albuquerque, A.P.B. Silva, A.L.V. Lima, C.A.D. Beltrão, E.I.C. |
| author_sort |
Albuquerque, A.P.B. |
| title |
FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| title_short |
FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| title_full |
FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| title_fullStr |
FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| title_full_unstemmed |
FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| title_sort |
fut3 expression in human breast cancer cells under hypoxia and serum deprivation |
| title_alt |
FUT3 expression in human breast cancer cells under hypoxia and serum deprivation |
| description |
Summary. This study aimed to investigate the effects of hypoxia and serum deprivation on regulation of fucosyltransferase-3 (FUT3) expression in breast cancer cells. Materials and Methods: FUT3 expression was evaluated in T47D and MCF7 cells. Transcriptional and protein analysis was performed under hypoxia and serum deprivation conditions after 6 and 24 hours; and after 24 and 48 hours, respectively. Results: In T47D cells, experimental conditions induced a significant decrease in FUT3 expression at both, transcriptional and protein levels, while in MCF7 cells the same conditions induced a significant increase of FUT3 expression. Conclusions: Regulation of FUT3 expression under hypoxic and serum deprivation conditions may be involved in the acquisition of advantages related to apoptosis resistance and metastasis promotion, according to the intrinsic differences presented by T47D and MCF7 cells. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-4 |
| work_keys_str_mv |
AT albuquerqueapb fut3expressioninhumanbreastcancercellsunderhypoxiaandserumdeprivation AT silvaalv fut3expressioninhumanbreastcancercellsunderhypoxiaandserumdeprivation AT limacad fut3expressioninhumanbreastcancercellsunderhypoxiaandserumdeprivation AT beltraoeic fut3expressioninhumanbreastcancercellsunderhypoxiaandserumdeprivation |
| first_indexed |
2025-07-17T12:16:38Z |
| last_indexed |
2025-07-17T12:16:38Z |
| _version_ |
1837896406003613696 |