Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia
Summary. According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populat...
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| Дата: | 2023 |
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PH Akademperiodyka
2023
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oai:ojs2.ex.aqua-time.com.ua:article-2352023-10-11T16:41:40Z Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia Ivanivska, T.S. Sklyarenko, L.M. Zavelevich, M.P. Philchenkov, A.A. Koval, S.V. Polishchuk, A.S. Gluzman, D.F. acute myeloid leukemia., bulk of blast cells, hematopoiesis, hematopoietic stem cells, leukemic stem cells, targeted therapy acute myeloid leukemia., bulk of blast cells, hematopoiesis, hematopoietic stem cells, leukemic stem cells, targeted therapy Summary. According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populations. This mini-review provides brief information on the distinctive features of LSC and blast cells in cytologically recognized types of AML. The study of different phenotypes of LSC and blast cells in AML with the aid of up-to-date flow cytometric techniques is important both for the deep insight into the mechanisms of leukemogenesis and development of novel strategies of target therapy. The urgent need for extending the diagnostic panel of monoclonal antibodies used for diagnosing AML is beyond doubt. Summary. According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populations. This mini-review provides brief information on the distinctive features of LSC and blast cells in cytologically recognized types of AML. The study of different phenotypes of LSC and blast cells in AML with the aid of up-to-date flow cytometric techniques is important both for the deep insight into the mechanisms of leukemogenesis and development of novel strategies of target therapy. The urgent need for extending the diagnostic panel of monoclonal antibodies used for diagnosing AML is beyond doubt. PH Akademperiodyka 2023-06-04 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-8 10.32471/exp-oncology.2312-8852.vol-41-no-3.13492 Experimental Oncology; Vol. 41 No. 3 (2019): Experimental Oncology; 207-209 Експериментальна онкологія; Том 41 № 3 (2019): Експериментальна онкологія; 207-209 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-8/2019-3-8 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
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| datestamp_date |
2023-10-11T16:41:40Z |
| collection |
OJS |
| language |
English |
| topic |
acute myeloid leukemia. bulk of blast cells hematopoiesis hematopoietic stem cells leukemic stem cells targeted therapy |
| spellingShingle |
acute myeloid leukemia. bulk of blast cells hematopoiesis hematopoietic stem cells leukemic stem cells targeted therapy Ivanivska, T.S. Sklyarenko, L.M. Zavelevich, M.P. Philchenkov, A.A. Koval, S.V. Polishchuk, A.S. Gluzman, D.F. Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| topic_facet |
acute myeloid leukemia. bulk of blast cells hematopoiesis hematopoietic stem cells leukemic stem cells targeted therapy acute myeloid leukemia. bulk of blast cells hematopoiesis hematopoietic stem cells leukemic stem cells targeted therapy |
| format |
Article |
| author |
Ivanivska, T.S. Sklyarenko, L.M. Zavelevich, M.P. Philchenkov, A.A. Koval, S.V. Polishchuk, A.S. Gluzman, D.F. |
| author_facet |
Ivanivska, T.S. Sklyarenko, L.M. Zavelevich, M.P. Philchenkov, A.A. Koval, S.V. Polishchuk, A.S. Gluzman, D.F. |
| author_sort |
Ivanivska, T.S. |
| title |
Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| title_short |
Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| title_full |
Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| title_fullStr |
Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| title_full_unstemmed |
Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| title_sort |
immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| title_alt |
Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia |
| description |
Summary. According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populations. This mini-review provides brief information on the distinctive features of LSC and blast cells in cytologically recognized types of AML. The study of different phenotypes of LSC and blast cells in AML with the aid of up-to-date flow cytometric techniques is important both for the deep insight into the mechanisms of leukemogenesis and development of novel strategies of target therapy. The urgent need for extending the diagnostic panel of monoclonal antibodies used for diagnosing AML is beyond doubt. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-8 |
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2025-07-17T12:16:51Z |
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2025-07-17T12:16:51Z |
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