The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia
Summary. Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q...
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| Дата: | 2018 |
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| Мова: | English |
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PH Akademperiodyka
2018
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-2812025-04-30T11:55:13Z The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia Tari, K. Shamsi, Z. Reza Ghafari, H. Atashi, A. Shahjahani, M. Abroun, S. chronic lymphocytic leukemia, epigenetics, genetic mutation chronic lymphocytic leukemia, epigenetics, genetic mutation Summary. Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL. Summary. Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL. PH Akademperiodyka 2018-12-22 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-3 Experimental Oncology; Vol. 40 No. 4 (2018): Experimental Oncology; 261-267 Експериментальна онкологія; Том 40 № 4 (2018): Експериментальна онкологія; 261-267 2312-8852 1812-9269 en https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-3/2018-4-3 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2025-04-30T11:55:13Z |
| collection |
OJS |
| language |
English |
| topic |
chronic lymphocytic leukemia epigenetics genetic mutation |
| spellingShingle |
chronic lymphocytic leukemia epigenetics genetic mutation Tari, K. Shamsi, Z. Reza Ghafari, H. Atashi, A. Shahjahani, M. Abroun, S. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| topic_facet |
chronic lymphocytic leukemia epigenetics genetic mutation chronic lymphocytic leukemia epigenetics genetic mutation |
| format |
Article |
| author |
Tari, K. Shamsi, Z. Reza Ghafari, H. Atashi, A. Shahjahani, M. Abroun, S. |
| author_facet |
Tari, K. Shamsi, Z. Reza Ghafari, H. Atashi, A. Shahjahani, M. Abroun, S. |
| author_sort |
Tari, K. |
| title |
The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| title_short |
The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| title_full |
The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| title_fullStr |
The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| title_full_unstemmed |
The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| title_sort |
role of the genetic abnormalities, epigenetic and microrna in the prognosis of chronic lymphocytic leukemia |
| title_alt |
The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia |
| description |
Summary. Chronic lymphocytic leukemia (CLL) is increased proliferation of B-cells with peripheral blood and bone marrow involvement, which is usually observed in older people. Genetic mutations, epigenetic changes and miRs play a role in CLL pathogenesis. Del 11q, del l17q, del 6q, trisomy 12, p53 and IgVH mutations are the most important genetic changes in CLL. Deletion of miR-15a and miR-16a can increase bcl2 gene expression, miR-29 and miR-181 deletions decrease the expression of TCL1, and miR-146a deletion prevents tumor metastasis. Epigenetic changes such as hypo- and hypermethylation, ubiquitination, hypo- and hyperacetylation of gene promoters involved in CLL pathogenesis can also play a role in CLL. Expression of CD38 and ZAP70, presence or absence of mutation in IgVH and P53 mutation are among the factors involved in CLL prognosis. Use of monoclonal antibodies against surface markers of B-cells like anti-CD20 as well as tyrosine kinase inhibitors are the most important therapeutic approaches for CLL. |
| publisher |
PH Akademperiodyka |
| publishDate |
2018 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-3 |
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