Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas
Summary. Background: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the st...
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PH Akademperiodyka
2018
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oai:ojs2.ex.aqua-time.com.ua:article-285 |
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Experimental Oncology |
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2025-04-30T11:55:13Z |
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English |
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breast cancer of luminal A and basal subtypes mitochondrial ribosomal protein S18-2 MRPS18-2 |
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breast cancer of luminal A and basal subtypes mitochondrial ribosomal protein S18-2 MRPS18-2 Buchynska, L.G. Iurchenko, N.P. Kashuba, E.V. Brieieva, O.V. Glushchenko, N.M. Mints, M. Lukianova, N.Yu. Chekhun, V.F. Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| topic_facet |
breast cancer of luminal A and basal subtypes mitochondrial ribosomal protein S18-2 MRPS18-2 breast cancer of luminal A and basal subtypes mitochondrial ribosomal protein S18-2 MRPS18-2 |
| format |
Article |
| author |
Buchynska, L.G. Iurchenko, N.P. Kashuba, E.V. Brieieva, O.V. Glushchenko, N.M. Mints, M. Lukianova, N.Yu. Chekhun, V.F. |
| author_facet |
Buchynska, L.G. Iurchenko, N.P. Kashuba, E.V. Brieieva, O.V. Glushchenko, N.M. Mints, M. Lukianova, N.Yu. Chekhun, V.F. |
| author_sort |
Buchynska, L.G. |
| title |
Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| title_short |
Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| title_full |
Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| title_fullStr |
Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| title_full_unstemmed |
Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| title_sort |
overexpression of the mitochondrial ribosomal protein s18-2 in the invasive breast carcinomas |
| title_alt |
Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas |
| description |
Summary. Background: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p < 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients. |
| publisher |
PH Akademperiodyka |
| publishDate |
2018 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-7 |
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AT buchynskalg overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT iurchenkonp overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT kashubaev overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT brieievaov overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT glushchenkonm overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT mintsm overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT lukianovanyu overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas AT chekhunvf overexpressionofthemitochondrialribosomalproteins182intheinvasivebreastcarcinomas |
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2025-07-17T12:17:25Z |
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2025-07-17T12:17:25Z |
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oai:ojs2.ex.aqua-time.com.ua:article-2852025-04-30T11:55:13Z Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas Buchynska, L.G. Iurchenko, N.P. Kashuba, E.V. Brieieva, O.V. Glushchenko, N.M. Mints, M. Lukianova, N.Yu. Chekhun, V.F. breast cancer of luminal A and basal subtypes, mitochondrial ribosomal protein S18-2, MRPS18-2 breast cancer of luminal A and basal subtypes, mitochondrial ribosomal protein S18-2, MRPS18-2 Summary. Background: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p < 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients. Summary. Background: Recent studies allow to consider the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) as a potential oncoprotein, which suggests the need for further characterization of its expression in tumors of different genesis including breast cancer (BC). The aim of the study was to analyze the expression of the S18-2 protein in BC of luminal A and basal subtypes. Materials and Methods: Operational material of BC patients stage І–ІІ (luminal A subtype, n = 30, and basal subtype, n = 10) was studied with the use of morphological, immunohistochemical, statistical and bioinformatic methods. Results: Using the immunohistochemical analysis, we found that the S18-2 protein showed the nuclear signal in 66.7% of luminal A subtype BC samples and 80.0% of basal subtype BC samples. The variability of the S18-2 expression in both the luminal A and basal subtypes of BC was revealed. Noteworthy, the number of cells expressing S18-2 in high-proliferating tumors of luminal A and basal subtype is significantly higher than in tumors with a low proliferative potential (p < 0.05). In 10 samples of luminal A subtype, the nuclear S18-2 signal was higher than median value. Moreover, the S18-2 protein was overexpressed in 4 out of such 10 samples. Metastases in the lymph nodes were found in 3 out of 4 patients with the stage II BC, low differentiation grade of the tumor and high proliferative activity. The bioinformatic analysis confirms our preliminary findings that the trend for increasing expression of the S18-2 protein in tumors correlates with the aggressiveness of malignant BC. Conclusion: The S18-2 protein may be a marker of cancer aggressiveness in BC patients. PH Akademperiodyka 2018-12-22 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-7 Experimental Oncology; Vol. 40 No. 4 (2018): Experimental Oncology; 303-308 Експериментальна онкологія; Том 40 № 4 (2018): Експериментальна онкологія; 303-308 2312-8852 1812-9269 en https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-7/2018-4-7 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |