ЕКСПРЕСІЯ РЕЦЕПТОРА ПРОГРАМОВАНОЇ КЛІТИННОЇ ЗАГИБЕЛІ У ХВОРИХ НА РАК ЕНДОМЕТРІЯ З МЕТАБОЛІЧНИМИ ПОРУШЕННЯМИ
Aim: To study the expression of the programmed cell death receptor (PD-1) and its ligand (PD-L1) by immunocompetent cells in endometrial cancer patients with metabolic disorders. Materials and Methods: Populations and subpopulations of lymphocytes were analyzed by flow cytometry. Antibodies against...
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| Date: | 2023 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
PH Akademperiodyka
2023
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| Subjects: | |
| Online Access: | https://exp-oncology.com.ua/index.php/Exp/article/view/2023-1-4 |
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| Journal Title: | Experimental Oncology |
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Experimental Oncology| Summary: | Aim: To study the expression of the programmed cell death receptor (PD-1) and its ligand (PD-L1) by immunocompetent cells in endometrial cancer patients with metabolic disorders. Materials and Methods: Populations and subpopulations of lymphocytes were analyzed by flow cytometry. Antibodies against CD279 were used to detect PD-1 on the CD4+ and CD8+ T cells. Antibodies against CD14 and CD274 were used to detect PD-L1 on monocytes. Results: In patients with severe metabolic disorders, the expression of PD-1 on CD8+ and CD4+ lymphocytes and the expression of the corresponding PD-L1 on CD14+ cells before treatment and after radiation therapy were higher than in the control group. Conclusion: Theincreased expression of PD-1 and PD-L1 receptors by immunocompetent cells can be considered a new prognostic marker in endometrial cancer patients with morbid obesity. |
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