Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом
A number of new hydrazones with biological activity are synthesized on the basis of 5-nitroindazole. The most efficient conditions of their synthesis with maximum reaction yield are established. The chemical structure of new compounds is found by the elemental analysis, FTIR spectroscopy, and 1H-NMR...
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| Datum: | 2018 |
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ujp2-article-20184462019-03-29T09:05:22Z Optimized Synthesis and Spectral Characterization of Some Hydrazones Based on 5-Nitroindazole with Pharmacological Potential Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом Cheptea, C. Ivan, L. M. Dorohoi, D. O. Sunel, V. Hurjui, I. Saveanu, C. I. Galaction, A. I. Hydrazones HyperChem antitumor effect A number of new hydrazones with biological activity are synthesized on the basis of 5-nitroindazole. The most efficient conditions of their synthesis with maximum reaction yield are established. The chemical structure of new compounds is found by the elemental analysis, FTIR spectroscopy, and 1H-NMR method. The data of spectral analysis were verified by calculations with the HyperChem software. Toxicological tests indicate that the synthesized hydrazones have the antitumor effect. Синтезовано ряд нових гiдразонiв з бiологiчною активнiстю на основi 5-нiтроiндазола. Встановлено найбiльш ефективнi умови їх синтезу з максимальним виходом реакцiї. Хiмiчна структура нових сполук визначена елементним аналiзом i методами iнфрачервоної спектроскопiї з фур’є-перетворенням i ЯМР. Данi спектрального аналiзу перевiренi розрахунками з програмою HyperChem. Токсикологiчнi тести свiдчать про те, що синтезованi гiдразони володiють антипухлинним ефектом. Publishing house "Academperiodika" 2018-10-19 Article Article Peer-reviewed Рецензована стаття application/pdf https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2018446 10.15407/ujpe59.03.0313 Ukrainian Journal of Physics; Vol. 59 No. 3 (2014); 313 Український фізичний журнал; Том 59 № 3 (2014); 313 2071-0194 2071-0186 10.15407/ujpe59.03 en https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2018446/452 Copyright (c) 2018 Bogolyubov Institute for Theoretical Physics, National Academy of Sciences of Ukraine |
| institution |
Ukrainian Journal of Physics |
| collection |
OJS |
| language |
English |
| topic |
Hydrazones HyperChem antitumor effect |
| spellingShingle |
Hydrazones HyperChem antitumor effect Cheptea, C. Ivan, L. M. Dorohoi, D. O. Sunel, V. Hurjui, I. Saveanu, C. I. Galaction, A. I. Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| topic_facet |
Hydrazones HyperChem antitumor effect |
| format |
Article |
| author |
Cheptea, C. Ivan, L. M. Dorohoi, D. O. Sunel, V. Hurjui, I. Saveanu, C. I. Galaction, A. I. |
| author_facet |
Cheptea, C. Ivan, L. M. Dorohoi, D. O. Sunel, V. Hurjui, I. Saveanu, C. I. Galaction, A. I. |
| author_sort |
Cheptea, C. |
| title |
Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| title_short |
Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| title_full |
Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| title_fullStr |
Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| title_full_unstemmed |
Оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| title_sort |
оптимiзацiя синтезу i спектральна характеристика нових гiдразонiв на основi 5-нiтроiндазола з фармакологiчним потенцiалом |
| title_alt |
Optimized Synthesis and Spectral Characterization of Some Hydrazones Based on 5-Nitroindazole with Pharmacological Potential |
| description |
A number of new hydrazones with biological activity are synthesized on the basis of 5-nitroindazole. The most efficient conditions of their synthesis with maximum reaction yield are established. The chemical structure of new compounds is found by the elemental analysis, FTIR spectroscopy, and 1H-NMR method. The data of spectral analysis were verified by calculations with the HyperChem software. Toxicological tests indicate that the synthesized hydrazones have the antitumor effect. |
| publisher |
Publishing house "Academperiodika" |
| publishDate |
2018 |
| url |
https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2018446 |
| work_keys_str_mv |
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| first_indexed |
2023-03-24T08:55:48Z |
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2023-03-24T08:55:48Z |
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