Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide
Aim: Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with DMSO. Methods: 153 HC graft infusions in 153 co...
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| Date: | 2009 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2009
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| Series: | Experimental Oncology |
| Subjects: | |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/135722 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients — impact of cryopreservation with dimethylsulfoxide / J.M. Horacek, L. Jebavy, M. Jakl, P. Zak, P. Mericka, J. Maly // Experimental Oncology. — 2009. — Т. 31, № 2. — С. 121–122. — Бібліогр.: 15 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Aim: Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study
aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with
DMSO. Methods: 153 HC graft infusions in 153 consecutive hematological patients (mean age 49.1 ± 12.6 years; 80 males) were
evaluated. Cryopreservation with DMSO was used in 133 grafts (DMSO group). Twenty grafts were infused directly without cryopreservation
(control group). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR were measured immediately
before and after HC graft infusion. Results: SBP and DBP increased significantly after graft infusions cryopreserved with DMSO
(p < 0.0001 for SBP; p < 0.01 for DBP). Increases (> 10 mmHg) in SBP were seen in 42 (31.6%) patients; in DBP in 31 (23.3%)
patients. Changes in HR were non-significant in DMSO group. Increases in BP and HR correlated with increasing DMSO dose
(p < 0.01; p < 0.05, respectively). Changes in SBP, DBP and HR were non-significant in control group. Conclusion: HC graft
infusions cryopreserved with DMSO could cause statistically significant increases in SBP and DBP, without changes in HR. These
changes were mostly transient and asymptomatic, not requiring therapeutic intervention. However, they might cause complications,
especially in patients with preexisting cardiovascular disease, who should be monitored closely during HC transplantation. |
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