Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity

Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity

Aim: To evaluate antitumor effect of plant polyphenol extracts from green tea, red wine lees and/or lemon peel alone and in combination with antitumor drugs on the growth of different transplanted tumors in experimental animals. Materials and Methods: Green tea extract (GTE) was prepared from green...

Повний опис

Збережено в:
Бібліографічні деталі
Дата:2015
Автори: Zaletok, S., Gulua, L., Wicker, L., Shlyakhovenko, V., Gogol, S., Orlovsky, O., Karnaushenko, O., Verbinenko, A., Milinevska, V., Samoylenko, O., Todor, I., Turmanidze, T.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
Назва видання:Experimental Oncology
Теми:
Original contributions
Онлайн доступ:http://dspace.nbuv.gov.ua/handle/123456789/145554
Теги: Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity / S. Zaletok, L. Gulua, L. Wicker, V. Shlyakhovenko, S. Gogol, O. Orlovsky, O. Karnaushenko, A. Verbinenko, V. Milinevska, O. Samoylenko, I. Todor, T. Turmanidze // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 262-271. — Бібліогр.: 45 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id irk-123456789-145554
record_format dspace
fulltext
spelling irk-123456789-1455542019-01-24T01:23:03Z Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity Zaletok, S. Gulua, L. Wicker, L. Shlyakhovenko, V. Gogol, S. Orlovsky, O. Karnaushenko, O. Verbinenko, A. Milinevska, V. Samoylenko, O. Todor, I. Turmanidze, T. Original contributions Aim: To evaluate antitumor effect of plant polyphenol extracts from green tea, red wine lees and/or lemon peel alone and in combination with antitumor drugs on the growth of different transplanted tumors in experimental animals. Materials and Methods: Green tea extract (GTE) was prepared from green tea infusion. GTE-based composites of red wine (GTRW), lemon peel (GTRWL) and/or NanoGTE as well as corresponding nanocomposites were prepared. The total polyphenolics of the different GTE-based extracts ranged from 18.0% to 21.3%. The effects of GTE-based extracts were studied in sarcoma 180, Ehrlich carcinoma, B16 melanoma, Ca755 mammary carcinoma, P388 leukemia, L1210 leukemia, and Guerin carcinoma (original, cisplatin-resistant and doxorubicin-resistant variants). The extracts were administered as 0.1% solution in drinking water (0.6–1.0 mg by total polyphenolics per mouse per day and 4.0–6.3 mg per rat per day). Results: Tumor growth inhibition (TGI) in mice treated with NanoGTE, cisplatin or cisplatin + NanoGTE was 27%, 55% and 78%, respectively, in Sarcoma 180%, 21%, 45% and 59%, respectively, in Ehrlich carcinoma; and 8%, 13% and 38%, respectively in B16 melanoma. Composites of NanoGTE, red wine, and lemon peel (NanoGTRWL) enhanced the antitumor effects of cyclophosphamide in mice with Ca755 mammary carcinoma. The treatment with combination of NanoGTE and inhibitors of polyamines (PA) synthesis (DFMO + MGBG) resulted in significant TGI of P388 leukemia (up to 71%) and L1210 leukemia. In rats transplanted with Guerin carcinoma (parental strain), treatment with GTRW or GTE alone resulted in 25–28% TGI vs. 55–68% TGI in cisplatin-treated animals. The inhibition observed in the case of combination of GTE or GTRW with cisplatin was additive giving 81–88% TGI. Similar effects were observed when combinations of the cytostatics with GTE (or ­NanoGTE) were tested against cisplatin- or doxorubicin-resistant Guerin carcinoma. Moreover, the plant extracts lowered side toxicity of the drugs. Treatment with GTE, NanoGTE, and NanoGTRW decreased the levels of malondialdehyde in heart, kidney and liver tissue of experimental animals, as well as the levels of urea and creatinine in blood serum, increased erythrocyte and platelet counts, hemoglobin content, and decreased leucocyte counts. Conclusion: The obtained data indicate the prospects for further deve­lopment of GTE and corresponding nanocomposites as auxiliary agents in cancer chemotherapy. Key Words: polyphenolic plant extracts, antitumor effect, cancer therapy. 2015 Article Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity / S. Zaletok, L. Gulua, L. Wicker, V. Shlyakhovenko, S. Gogol, O. Orlovsky, O. Karnaushenko, A. Verbinenko, V. Milinevska, O. Samoylenko, I. Todor, T. Turmanidze // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 262-271. — Бібліогр.: 45 назв. — англ. 1812-9269 http://dspace.nbuv.gov.ua/handle/123456789/145554 en Experimental Oncology Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Original contributions
Original contributions
spellingShingle Original contributions
Original contributions
Zaletok, S.
Gulua, L.
Wicker, L.
Shlyakhovenko, V.
Gogol, S.
Orlovsky, O.
Karnaushenko, O.
Verbinenko, A.
Milinevska, V.
Samoylenko, O.
Todor, I.
Turmanidze, T.
Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
Experimental Oncology
description Aim: To evaluate antitumor effect of plant polyphenol extracts from green tea, red wine lees and/or lemon peel alone and in combination with antitumor drugs on the growth of different transplanted tumors in experimental animals. Materials and Methods: Green tea extract (GTE) was prepared from green tea infusion. GTE-based composites of red wine (GTRW), lemon peel (GTRWL) and/or NanoGTE as well as corresponding nanocomposites were prepared. The total polyphenolics of the different GTE-based extracts ranged from 18.0% to 21.3%. The effects of GTE-based extracts were studied in sarcoma 180, Ehrlich carcinoma, B16 melanoma, Ca755 mammary carcinoma, P388 leukemia, L1210 leukemia, and Guerin carcinoma (original, cisplatin-resistant and doxorubicin-resistant variants). The extracts were administered as 0.1% solution in drinking water (0.6–1.0 mg by total polyphenolics per mouse per day and 4.0–6.3 mg per rat per day). Results: Tumor growth inhibition (TGI) in mice treated with NanoGTE, cisplatin or cisplatin + NanoGTE was 27%, 55% and 78%, respectively, in Sarcoma 180%, 21%, 45% and 59%, respectively, in Ehrlich carcinoma; and 8%, 13% and 38%, respectively in B16 melanoma. Composites of NanoGTE, red wine, and lemon peel (NanoGTRWL) enhanced the antitumor effects of cyclophosphamide in mice with Ca755 mammary carcinoma. The treatment with combination of NanoGTE and inhibitors of polyamines (PA) synthesis (DFMO + MGBG) resulted in significant TGI of P388 leukemia (up to 71%) and L1210 leukemia. In rats transplanted with Guerin carcinoma (parental strain), treatment with GTRW or GTE alone resulted in 25–28% TGI vs. 55–68% TGI in cisplatin-treated animals. The inhibition observed in the case of combination of GTE or GTRW with cisplatin was additive giving 81–88% TGI. Similar effects were observed when combinations of the cytostatics with GTE (or ­NanoGTE) were tested against cisplatin- or doxorubicin-resistant Guerin carcinoma. Moreover, the plant extracts lowered side toxicity of the drugs. Treatment with GTE, NanoGTE, and NanoGTRW decreased the levels of malondialdehyde in heart, kidney and liver tissue of experimental animals, as well as the levels of urea and creatinine in blood serum, increased erythrocyte and platelet counts, hemoglobin content, and decreased leucocyte counts. Conclusion: The obtained data indicate the prospects for further deve­lopment of GTE and corresponding nanocomposites as auxiliary agents in cancer chemotherapy. Key Words: polyphenolic plant extracts, antitumor effect, cancer therapy.
format Article
author Zaletok, S.
Gulua, L.
Wicker, L.
Shlyakhovenko, V.
Gogol, S.
Orlovsky, O.
Karnaushenko, O.
Verbinenko, A.
Milinevska, V.
Samoylenko, O.
Todor, I.
Turmanidze, T.
author_facet Zaletok, S.
Gulua, L.
Wicker, L.
Shlyakhovenko, V.
Gogol, S.
Orlovsky, O.
Karnaushenko, O.
Verbinenko, A.
Milinevska, V.
Samoylenko, O.
Todor, I.
Turmanidze, T.
author_sort Zaletok, S.
title Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
title_short Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
title_full Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
title_fullStr Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
title_full_unstemmed Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
title_sort green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
publishDate 2015
topic_facet Original contributions
url http://dspace.nbuv.gov.ua/handle/123456789/145554
citation_txt Green tea, red wine and lemon extracts reduce experimental tumor growth and cancer drug toxicity / S. Zaletok, L. Gulua, L. Wicker, V. Shlyakhovenko, S. Gogol, O. Orlovsky, O. Karnaushenko, A. Verbinenko, V. Milinevska, O. Samoylenko, I. Todor, T. Turmanidze // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 262-271. — Бібліогр.: 45 назв. — англ.
series Experimental Oncology
work_keys_str_mv AT zaletoks greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT gulual greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT wickerl greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT shlyakhovenkov greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT gogols greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT orlovskyo greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT karnaushenkoo greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT verbinenkoa greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT milinevskav greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT samoylenkoo greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT todori greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
AT turmanidzet greentearedwineandlemonextractsreduceexperimentaltumorgrowthandcancerdrugtoxicity
first_indexed 2025-07-10T21:56:54Z
last_indexed 2025-07-10T21:56:54Z
_version_ 1837298738443321344

Схожі ресурси