Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms
In experiments on mice, we examined the effects of 3-min-long forced swimming sessions on indices characterizing the state of the nociceptive system. Thirty minutes after the forced swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate and tail flick...
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| Date: | 2013 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2013
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| Series: | Нейрофизиология |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/148127 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Forced Swimming Stress-Related Hypoalgesia: Nondependence on the Histaminergic Mechanisms / G.F. Ibironke, K.S. Rasak // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 380-384. — Бібліогр.: 19 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | In experiments on mice, we examined the effects of 3-min-long forced swimming sessions
on indices characterizing the state of the nociceptive system. Thirty minutes after the forced
swimming episode, significantly lower (P < 0.05) latencies of motor reactions in the hot plate
and tail flick tests were observed.At the same time, times of licking the paw within the early and
late phases of the formalin test, as well as numbers of writhings in the acetic acid test, became
significantly(P<0.05)smaller.Thus,forcedswimming-inducedstressresultsinthedevelopment
of a hypoalgesia state with respect to thermoinduced pain and chemoinduced somatic (formalin
test) and visceral (acetic acid test) pain. Blockers of histamine H1 (cimetidine, 10 mg/kg)
and H2 (chlorpheniramine, 15 mg/kg) receptors did not influence significantly (P > 0.05)
the intensity of forced swimming-induced hypoalgesia in the tail flick and acetic acidinduced (writhing) tests. Thus, the histaminergic system is not significantly involved in the
mechanisms of forced swimming-induced hypoalgesia. |
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