Penicillin-Induced Epileptiform Ecog Activity in Gerbils: Effects of Physical Exercise and a Diospyros Kaki Extract
Mongolian gerbils (28 males) were divided into four groups, control (C), treadmill-exercised (Ex), treated with the extract of Diospyros kaki (Dk), and treated with the Dk extract plus exercised (Ex+Dk) groups. Animals of the respective groups were running-exercised for 30 min per day during 8 we...
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| Date: | 2016 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2016
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| Series: | Нейрофизиология |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/148401 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Penicillin-Induced Epileptiform Ecog Activity in Gerbils: Effects of Physical Exercise and a Diospyros Kaki Extract / Y. Kayacan, A. Bahadir, A. Cetinkaya, H. Orallar, S. Cakir, E. Beyazcicek, A.C. Onal, A. Yildirim // Нейрофизиология. — 2016. — Т. 48, № 5. — С. 406-414. — Бібліогр.: 29 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | Mongolian gerbils (28 males) were divided into four groups, control (C), treadmill-exercised
(Ex), treated with the extract of Diospyros kaki (Dk), and treated with the Dk extract plus
exercised (Ex+Dk) groups. Animals of the respective groups were running-exercised for
30 min per day during 8 weeks, and the Dk extract (dose 20mg/kg) was given by gavage
during five days per week within the same period. After the treatment and exercise period,
an epilepsy model was produced by penicillin G injection (500 IU) into the left somatomotor
cortex, and electrocorticogram (ECoG) was recorded during 120 min. The mean frequency of
spike/wave complexes was significantly smaller in the Ex and Ex+Dk groups from the 65th
min of the observation period and, in the Dk group, from the 75th min than the respective
value in the C group (P < 0.01, P < 0.05, and P < 0.01, respectively). The differences in the
amplitude values and latency to onset of the spike/wave events among all groups usally did
not reach the significance level (P > 0.05), but, visin late stages of the observation period,
an antiseisure effect of the Dk extract was obvious. Thus, both the running exercise and
Dk extract applications inhibit penicillin-induced epileptiform activity by altering the spike/
wave frequency or severity of seizures observed in ECoG recordings. Further studies are
needed to determine the effects of physical activity of different intensities and forms and to
analyze the active compounds in the Dk extract. |
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