Gender Specificity of Genistein Treatment in Penicillin-Induced Epileptiform Activity in Rats
We investigated gender-dependent differences of genistein (isoflavone phytoestrogen) treatment in a penicillin-induced experimental epilepsy rat model. Twenty-eight adult Wistar Albino rats (14 females and 14 males) were devided into four groups, control and genisteintreatmed males and females. Ge...
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| Date: | 2016 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2016
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| Series: | Нейрофизиология |
| Online Access: | http://dspace.nbuv.gov.ua/handle/123456789/148440 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Gender Specificity of Genistein Treatment in Penicillin-Induced Epileptiform Activity in Rats / A. Bahadir, S. Demir, H. Orallar, E. Beyazcicek, A. Cetinkaya, S. Ankarali, H. Ankarali // Нейрофизиология. — 2016. — Т. 48, № 6. — С. 469-476. — Бібліогр.: 30 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | We investigated gender-dependent differences of genistein (isoflavone phytoestrogen)
treatment in a penicillin-induced experimental epilepsy rat model. Twenty-eight adult Wistar
Albino rats (14 females and 14 males) were devided into four groups, control and genisteintreatmed males and females. Genistein (100 µg/kg, i.p) or saline was given during 15 days
before the electrocorticography (ECoG) recordings. The epileptiform activity was induced
by penicillin G potassium solt (500 IU, i.c) injections into the left somatomotor cortex.
Significant differences among the groups were found in the latency to onset of epileptiform
activity. This value in the female control group was significantly longer than the latencies in
the male control, male genistein, and female genistein groups (respectively, P = 0.002, 0.015,
and 0.032). There were no significant differences regarding the spike/wave frequencies and
amplitudes in epileptiform activity between female/male genistein and control groups within
all observation intervals (P > 0.05). Thus, genistein exerts a proconvulsant effect in the
penicillin-induced epilepsy model, and the effect demonstrates the clear gender specificity
related to the specificity of hormonal backgrounds in males and females. |
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