Synthesis of a new spirocyclic γ-lactam derivatives from 3-halogeno-3-trifluoroacetyl-1-methyl-2-pyrrolidinones
3-Bromo and 3-chloro-3-trifluoroacetyl-1-methyl-2-pyrrolidinones have been obtained by the halogenation reaction of the corresponding 3-trifluoroacetyl derivatives. These compounds were fully characterized as hydrates after simple filtration on silica gel. Reactions of 3-halogeno-3-trifluoroacetyl d...
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| Datum: | 2007 |
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| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут органічної хімії НАН України
2007
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| Schriftenreihe: | Журнал органічної та фармацевтичної хімії |
| Online Zugang: | http://dspace.nbuv.gov.ua/handle/123456789/42307 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Synthesis of a new spirocyclic γ-lactam derivatives from 3-halogeno-3-trifluoroacetyl-1-methyl-2-pyrrolidinones / Jean-Philippe Bouillon // Журнал органічної та фармацевтичної хімії. — 2007. — Т. 5, вип. 4(20). — С. 3-9. — Бібліогр.: 28 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | 3-Bromo and 3-chloro-3-trifluoroacetyl-1-methyl-2-pyrrolidinones have been obtained by the halogenation reaction of the corresponding 3-trifluoroacetyl derivatives. These compounds were fully characterized as hydrates after simple filtration on silica gel. Reactions of 3-halogeno-3-trifluoroacetyl derivatives with benzathioamide and benzamidine lead to the formation of new spirocyclic γ-lactams in moderate yields and the corresponding product of the dehalogenation of the starting substance. |
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